Christine DeWolf, PhD

Research interests

Biophysical, Environment, Organic, and Physical Chemistry.

Education

Postdoctoral fellow

Max-Planck Institute of Colloids and Interfaces

Current research projects

Interaction of antimicrobial peptides with model membranes

Pollutant damage to air-exposed membranes

Nanocarriers for drug delivery

Langmuir monolayer structure and organization

Tailored surfaces for biocompatibility, biosensing and bio-targeting

Functional thin film architectures

• CHEM 234: Physical Chemistry I
• CHEM 335: Biophysical Chemistry
• CHEM 451: Nanochemistry
• CHEM 435: Interfacial Phenomena

Recent publications

N. Bondon, G. Mandl, P. A. M. Giraldo,Z.Ferron, N. Sadeghipour, C. DeWolf, J.A. Capobianco (2025). Enhancing X-ray Activated Photodynamic Therapy with Supported Lipid Bilayer-Coated Radioluminescent Nanoparticles, Langmuir 2025,41, 41, 27794–27803.

D.M. dos Santos, R.J.G. Rubira, G.P. Salzedas,M.B. Kobal, L.G. Moreira,K.A. Toledo, P.H.B. Aoki, C. DeWolf, S.A. Camacho(2025). Elucidating the Toxicity of Regulated Concentrations of MethylParathion, Imazapic, Isoxaflutole, and Chlorantraniliprole on Human Hepatocarcinoma Cells and Bioinspired Membranes, Journal of Hazardous Materials, 490, 137712.

A. Ferreira, A. Mendes deAlmeida Jr, M. Kobal,L. Gontijo Moreira, S. Camacho, K. de Toledo, O.Oliveira, C. DeWolf, P.H.B.Aoki (2025). Photoactivated Rose Bengal Triggers Phospholipid Hydroperoxidation and Late Apoptosis in Colorectal Cancer Cells, Langmuir,41,6789-6800.

Z. Alinia, D. Miao,T.Baumgartner, C. DeWolf (2024). Self-assembly of Phosphole-lipids in 2D Films: The Influence ofπ-Interactions and StericConstraints, RSC Applied Interfaces, 2,460-471

Z. Alinia, E. Abdulhamied, S.Selmani, R.Miclette Lamarche, S. H. Eichhorn, C. E. DeWolf (2024). Amphiphilicity of Tetraazaporphyrins Containing Four Terminal Carboxylic Acid and Four Alkyl Groups Promotes Face-on Orientation in Langmuir Films, Langmuir, 40(50),26672-26684.

Z. Alinia, D. Miao, T.Baumgartner, C. DeWolf (2024). Tuning Electrostatics to Promote Ordered Monolayers of Phosphole-Lipids, Langmuir, 40,22301-22313.

P. Taktikakis, M. Côté, N. Subramaniam, K.Kroeger, H. Youssef, A.Badia, C. DeWolf (2024). Understanding the Retention ofVaping Additives in the Lungs: Model Lung Surfactant Membrane Perturbation byVitamin E and Vitamin E Acetate. Langmuir, 40 (11), 5651-5662. 

D. Kim, G. A. Mandl, M. Balkota, J. Vernaz, S.Huang, S. Constant,P.Maechler, C. DeWolf, J.A. Capobianco, L. Bonancina,(2023), The Effect of a Lipid Surface Coating on the Permeation ofUpconverting Nanoparticles through a 3D Human Lung Epithelial Model, Advanced Functional Materials, 34(11), 2310078.

M. Keramatnejad, C. DeWolf(2023), Impact of pollutant ozone on the biophysical properties of tear film model membranes, Membranes, 13(2), 165.

D. Ali, L. Dominguez, B. Findlay, A. Badia, C.DeWolf  (2023) Plant-derived phytoglycogenas a nanocarrier for the delivery of antimicrobial peptides, Langmuir, 39 (1)53-63.

M. Keramatnejad, C. DeWolf(2023), A BiophysicalStudy of tear Film Lipid Layer Model Membranes, BBA –Biomembranes, 1865(3), 1844102.

L.S.A. Pereia, A.A. Camacho, A.M.Almeida Jr., R.S. Goncalves, W. Caetano, C.E. DeWolf, P.H.B. Aoki (2022),Mechanisms of hypericin incorporation to explain the photooxidation outcomes inphospholipid biomembrane models, Chemistry and Physics of Lipids, 244, 105181.

X. Yan, K. Kumar, R. Miclette-Lamarche, H.Youssef, C.E. DeWolf, D.E. Warschawski,I. Marcotte, G. Shaw, E. Boisellier(2021). Interactions between S100A10 andphospholipid monolayers and bilayers,Langmuir, 37(32), 9652-9663.

L.Gravel-Tatta, C. DeWolf, A. Badia (2021) (CDand AB co-corresponding authors),Are Plant-based carbohydrate nanoparticlessafe for inhalation? Investigatingtheir interactions with the pulmonarysurfactant using Langmuir monolayers,Langmuir, 37(42), 12365-12376.

E.C. Wrobel, L.S. de Lara, T.A.S. do Carmo, P.Castellen, M. Lazzarotto, S.R. DeLázaro, A. Camilo Jr., L. Caseli, R. Schmidt,C.E. DeWolf, K. Wohnrath (2020),Study of the antibacterial activity ofp-tert-butylcalix[6]arene and its effecton a membrane model: Molecular Dynamicsand Langmuir films studies, PCCP, 22,6154-6166.

H.  Youssef, C. DeWolf (2020) InterfacialSelf-Assembly of Antimicrobial Peptide GL13K into Non-Fibril Crystallineβ‑Sheets,Langmuir, 36, 660-665

R.Miclette Lamarche, C. DeWolf (2020)omega-Thiolation of phenolic surfactantsenables controlled conversion betweenextended, bolaform and multilayerconformations, Langmuir, 36(11), 2847-2857.

A.R.N.Bastos, C.D.S Brites, P.A.Rojas-Gutierrez, R.A.S. Ferreira, R.L. Longo, C. DeWolf, J.A. Capobianco, L.DCarlos (2020). Thermal properties of lipid bilayers derived from the transientheating regime of upconverting nanoparticles, Nanoscale, 12, 24169-24176.

X. Yan, F. Noël, I. Marcotte, C.  DeWolf,D. Warschawski, E. Boisselier (2020) AHNAK C-terminal peptide membrane binding- Interactions between the residues 5654-5673 of AHNAK and phospholipidmonolayers and bilayers, Langmuir, 36, 1,362-369.

R. Miclette Lamarche, C. DeWolf (2019). Strong headgroup interactions drive highlydirectional growth and unusual phase co-existence in self-assembled phenolicfilms. ACS Applied Materials & Interfaces, 11, 48, 45354-45363.

ARN Bastos, CDS Brites, PARojas-Gutierrez, C DeWolf, RAS Ferreira, JA Capobianco, LD Carlos (2019). Thermal Properties of BilayersDetermined Using Upconversion Nanothermometry. Advanced Functional Materials,29 (48), 1905474.

P. Rojas-Gutierrez, D. Bekah, J.  Seuntjens, C.E. DeWolf, J.A.Capobianco (2019) Cellular Uptake, Cytotoxicity and Trafficking of SupportedLipid Bilayer Coated Lanthanide Upconverting Nanoparticles in Alveolar LungCancer Cells. ACS Applied Bio Materials, 2(10), 4527-4536.

S. Behyan, D. Gritzalis, R. Schmidt, E. Kebede,L.A. Cuccia, C. DeWolf(2019), Structural organization and phase behaviour ofmeta-substituteddioctadecylaminobenzoquinones at the air/water interface, PCCP,21, 2345-2350 (selected as 2019 hot article).

O. Borozenko, M. Faral, S. Behyan, A. Khan, M.Faral, C. DeWolf, A. Badia (2018) Silica Nanoparticle-Induced StructuralRe-organizations in Pulmonary Surfactant Films: What Monolayer CompressionIsotherms Do Not Say. ACS Applied Nano Materials, 1, 9, 5268-5278

P. Rojas-Gutierrez, C. Mingoes, S.Bhuckory, N.Hildebrandt, C. DeWolf, J.A. Capobianco (2018) A route to Triggered Deliveryvia Photocontrol of Lipid Bilayer Properties Using Lanthanide UpconversionNanoparticles. ACS Applied Nanomaterials, 1, 9, 5345-5354.

S. Behyan, O. Borozenko, A. Khan,M. Faral, A.Badia, C. DeWolf (2018) Nanoparticle-Induced Structural Changes in LungSurfactant Membranes: An X-ray Scattering Study. Environmental Science: Nano.,5; 1218-1230.