Circadian rhythms, Circadian clocks, Clock genes, Motivation, Stress, Glucocorticoids, Dopamine, mRNA translation control, Animal models of psychiatric disorders
Circadian clock genes encode transcriptional regulators that are central in the generation and regulation of circadian rhythms. Loss of function of core clock genes such as Bmal1 and Per2 is associated with loss of circadian rhythmicity and disturbances in a number cognitive, affective, and drug related behaviours. Members of my laboratory employ different animal models to study the regulation and function of clock genes in regions of the forebrain important in stress, motivation, and emotion. Using molecular, genetic, anatomical, and pharmacological methods in both male and female rodents, we study how the expression of core clock genes within functionally-defined forebrain structures is regulated by inputs from different regions of the brain; how these genes respond to behavioural, pharmacological, hormonal, and metabolic perturbations that disrupt homeostasis (e.g., changes in the external light cycle, stress, neurotransmitter manipulations, treatment with drugs of abuse, glucocorticoids, restricted feeding); and how disruption of clock gene expression within specific brain regions and cell types influence motivated and affective behaviours. Current research focuses on the role of the genes Bmal1 and Per2 within the striatum, habenula, and prefrontal cortex in depression and anxiety-related behaviours, motor functioning, and alcohol drinking behaviour.
Funding
Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), Fonds Nature et Technologies Quebec (FRQNT), Concordia University
Lab members
Konrad Schoettner, PhD, Research Associate/Lab manager
Christiane Meyer, PhD Candidate
Cassandra Goldfarb, PhD Candidate
Steven Dobric, MA Candidate
Juliana Herrera, MA Candidate
Jeremie Shabani, MA Candidate
Nour Quteishat, MA Candidate
Margo Button, Research Assistant
Barry Robinson, Resrach Techician and Lab administrator (1994-2014)
Kim Edelstein, MA, PhD (1992-1998)
Christian Beaulé, MA, PhD (1996-2002)
Jennifer Perrin, MA (2003-2005)
Elaine Waddington Lamont, PhD (2001-2005)
Lauren Segal, MA, PhD (2003-2010)
Suzanne Hood, PhD (2008-2010), Postdoctoral Fellow (2010-2011)
Luciana Gravotta, MA (2008-2010)
Michael Verwey, MA, PhD (2004-2011)
Valerie Harbour, MA, PhD (2005-2011)
Sherin Al-Safadi, PhD (2010-2014)
Doug Funk, Postdoctoral Fellow (1997-1999)
Andreas Arvanitogiannis, Postdoctoral Fellow (1997-1999)
Yuval Weigl, Postdoctoral Fellow (2007-2010)
Ruifeng Cao, Postdoctoral Fellow (2011-2016)
Ariana Frederick, MSc (2013-2016)
Hanna Opiol, PhD (2014-2019)
Sarah Ferarro, PhD (2015-2021)
Mariana Mayor, MA (2019-2021)
Miranda Benoit, MA (2016-2018)
Norhan Mehrez, MA (2018-2021)
Marylin Rackover, BA (1992-1993)
Jane Barry-Shaw, BA (2001-2002)
Shannon McShane, BA (2001-2002)
Laura Renteria Diaz, BA (2002-2003)
Nicolina Ratto, BA (2002-2003)
Lawrence Koby, BA (2002-2003)
Natsumi Sawada, BA (2005-2006)
Zoe Hsu, BA (2005-2006)
Zehra Khoja, BA (2005-2006)
Amel Oudhini, BA (2005-2006)
Sara-Claude Michon, BA (2005-2006)
Germain Lam, BA (2008-2009)
Pamela Cassidy, BA (2008-2009)
Marie Coriaty, BA (2010-2011)
Kristyn Gullander, BA (2012-2013)
Ariana Frederick, BA (2012-2013)
Marie Branchaud, BA (2014-2015)
Spencer Rutherford, BA (2014-2015)
Tara Delorme, BA (2016-2017)
Jory Goldsmith, BSc (2015-2017)
Gabriel Parent, BA (2018-2020)