Dr. Linda Booij , PhD
Associate Professor and Concordia University Research Chair in Eating Disorders, Psychology
FRQS Chercheur Boursier Senior
Co-Director, Centre for Clinical Research in Health (CCRH)
Numerous studies have shown that adverse exposures in utero or in the first years of life (e.g., malnutrition, emotional or physical abuse, harsh parenting) can lead to a variety of mental health difficulties later on. These difficulties include (but are not limited to) depression and eating disorders.
Early adverse exposures in utero or in the first years of life can affect the brain in many different ways; however, the neurotransmitter serotonin is of particular interest. That is because serotonin is (i) widely implicated in a variety of psychopathologies and (ii) important for brain development, especially during infancy or childhood (i.e., serotonin, in fact, helps to actually “build up the brain”). The overarching theme of our research program is that early adversity could disrupt the stability of certain brain chemicals (e.g., serotonin). This in turn influences the early development of brain regions involved in emotion regulation, and could predispose the individual to psychological problems later in life, particularly when exposed to subsequent stressful events. The studies we are conducting are done in clinical and non-clinical populations and use neuro-imaging (fMRI/PET), epigenetics (DNA methylation, HDACs) and/or cognitive-behavioural assessments, and is funded by various sources, including CIHR, NSERC, NARSAD and QBIN.
- Brain development and eating disorders
- Early risk factors, DNA methylation and eating disorders
- Emotional-cognitive processing in (risk for) eating disorders
- Gene-environment studies on brain and mental health, using twin designs
Dr. Booij is also a researcher at CHU Sainte-Justine and psychologist at the Continuum des troubles de l’alimentation of the CIUSSS de l'Ouest-de-l'Île-de-Montréal.
PhD (Leiden University, the Netherlands)
Mood, Anxiety and Personality Disorders (psyc440)
Models of Assessment I (psyc701)
Selected Recent Publications
Steiger, H., Booij, L., Singer, I., Crescenzi, O., Oliverio, S., Thaler, L., St-Hilaire, A., & Israel, M (2021). In-person versus virtual therapy in outpatient eating-disorder treatment: A COVID-19 inspired study. International Journal of Eating Disorders. Dec 14. doi: 10.1002/eat.23655.
Calancie, O.G., Brien, D.C, Huang, J., Coe, B.C., Booij, L., Khalid-Khan, S., & Munoz D.P. (2021). Maturation of temporal saccade prediction from childhood to adulthood: predictive saccades, reduced pupil size and blink synchronization. Journal of Neuroscience. doi: 10.1523/JNEUROSCI.0837-21.2021.
Mortaji, N., Krzeczkowski, J.E., Boylan, K., Booij, L., & Van Lieshout, R. (2021). Individual and joint effects of maternal pregnancy diet and postnatal home environment on executive function and behaviour in 3-4 year-olds. American Journal of Clinical Nutrition, 114(4):1418-1427. doi: 10.1093/ajcn/nqab202
Booij, L. Nicolosi, M. (2021). Early childhood care, support and research: how early screening and longitudinal studies can help children thrive. J de Pediatria, S0021-7557(21)00072-3. doi:10.1016/j.jped.2021.05.001
Khundrakpam, B., Tuerk, C., & Booij, L. (2021). Understanding heterogeneity in autism spectrum disorder: A methodological shift in neuroimaging research from investigating group differences to individual differences. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6: 762–764. doi:10.1016/j.bpsc.2021.04.004
Wu, Y., Marc, I., Bourchard, L., Ouyang, F., Luo, Z.C., Fan, J., Dubois, L., Mâsse, B., Zhang, J., Leung, P., Liao, X. P., Herba, C., Booij, L., Shen, J., Lewin, A., Jian, H., Wang, L., Xu, J., Wu, W., Sun, W., Wu, J., Li, H., Lei, C., Korzyrski, A., Semenic, S., Chaillet, N., Masse, L., Zhan, J., Knoppers, B., Baillargeon, J. P., Velez, M., Zhang, H., Yu, Y., Yu, W., Ding, Y., Vaillancourt, C., Liu, H., Tetu, A., Fang, W., Zhao, X., Jin, Y., Liu, X., Zhang, H., Chen, Z., Hao, Y., Abdoulahab, N., Fraser, W. D., & Huang, H.(2021). Community-Family-Mother-Child Intervention Study to Prevent Childhood Obesity: Study protocol for the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI)- a randomized controlled trial. BMJ open, 1, 11(4): e045192. doi:10.1136/bmjopen-2020-045192
Breton, É. & Booij, L. (2021). Du cerveau à l’assiette: Coup d’œil sur les troubles alimentaires. Revue Quebecoise, accepted.
Azar, N., Booij, L., Muckle, G., Arbuckle, T. E., Séguin, J. R., Asztalos, E., Fraser, W.D. Lanphear, B. Bouchard, M. F. (2021). Prenatal exposure to polybrominated diphenyl ethers (PBDEs) and cognitive ability in early childhood. Environment International, 146: 106296. doi:10.1016/j.envint.2020.106296.
Scardera, S., Sacco, S., DiSante, J., & Booij, L. (2021). Body image-related cognitive fusion: Role of disordered eating, self-compassion and sad mood. Eating and Weight Disorders, 46: 483-490. doi:10.1007/s40519-020-00868-w.
Porter-Vignola, E., Booij, L., Bossé-Chartier, G., Garel, P., & Herba, C. M. (2021). Emotional facial expression recognition and depression in adolescent girls: associations with clinical features. Psychiatry Research, 113777: 298:113777. doi:10.1016/j.psychres.2021.113777
Gouin, J-P., Thayer, J. F., Deschênes, S., MacNeil, S., & Booij, L. (2021). Implicit affect, heart rate variability, and the metabolic syndrome. Psychosomatic Medicine, 83: 24–32. doi:10.1097/PSY.0000000000000879.
Hayward, D.A., Pomares, F.B., Casey, K., Ismaylova, E., Levesque, M., Greenlaw, K., Vitaro, F., Brendgen, M., Dionne, G., Boivin, M., Tremblay, R.E., & Booij, L. (2020). Birth weight is associated with adolescent brain development: a multi-modal imaging study in monozygotic twins. Human Brain Mapping, Sep 2. doi: 10.1002/hbm.25188. Online ahead of print.
Sansfacon, J.**, Booij, L.**, Gauvin, L., Fletcher, F., Islam, F., Israel, M., & Steiger, H. (2020) Pre-treatment motivation and therapy outcomes in eating disorders: A systematic review and meta-analysis. International Journal of Eating Disorders, Sep 21. doi: 10.1002/eat.23376. Online ahead of print. . **SHARED first authorship.