Dr. Christopher L Brett, PhD
Co-Director, Centre for Microscopy at Concordia
Concordia University Research Chair in Applied Cell Science
Applied Science Hub,
7141 Sherbrooke W.
|Phone:||(514) 848-2424 ext. 3398|
Visit the Brett lab website
PhD (Johns Hopkins University)
PDF (University of Washington)
University Research Fellow, 2019
Dean's Award for Excellence in Scholarship, 2019
Distinguished Alumnus Lecture, Johns Hopkins University (Baltimore, USA), 2019
Canada Research Chair Tier 2, 2011-2016
Cell biology, synthetic biology, microscopy, lysosomes, extracellular vesicles, membrane trafficking, membrane fusion, nutrient transport, aging, cancer, Alzheimer's disease
*I am currently recruiting graduate (MSc, PhD) and undergrad (BSc Honours thesis, MITACS, USRA) students.
I am a cell physiologist and my research lab uses genetics, biochemistry, advanced microscopy and synthetic biology to study: (1) fundamental lysosome biology in health and disease, and (2) extracellular vesicles as novel therapeutics.
Whether they know it or not, everyone recycles. This is because every one of the billions of cells that make up you and I constantly recycle biomaterials using specialized tiny organelles called lysosomes. Lysosomes are an essential source of nutrients for cells and breakdown toxic biomaterials that accumulate as cells age. My lab uses baker's yeast (S. cerevisiae) and its vacuolar lysosome as models to study the molecular mechanisms underlying fundamental lysosome biology and how they promote longevity or contribute to age-related diseases.
Extracellular vesicles are tiny packages shared by all eukaryotic cells (from yeast to human) that mediate intercellular communication underlying diverse physiology, from immune responses to tissue development, suggesting they have enormous therapeutic potential. My group is using baker's yeast as a platform to engineer humanized yeast extracellular vesicles to hijack these processes with the aim of developing new therapeutic applications.
Cellular Neuroscience (BIOL 474/632E)
Comparative Animal Physiology (BIOL 382)