Paul Joyce, PhD
Professor, Chemistry and Biochemistry
Ph.D. (Dalhousie University)
Biochemistry, Genomics, Proteomics, Molecular/Cell Biology.
My primary teaching interest is in biochemistry. I regularly teach Biochemistry I (CHEM 271) and Biochemistry II (CHEM 375). Biochemistry I is an introductory course and covers the basics of biochemistry including enzymology, protein structure and metabolism. Biochemistry II covers more of the specific biochemical reactions involved in metabolic pathways. I also teach Discovering Biotechnology (CHEM 209) which is an introduction to the world of biotechnology for non-scientists. This course covers topics such as cloning and genetic engineering and includes discussions of the societal and ethical issues that are involved. In the past few years I have also taught advanced undergraduate and graduate courses in Protein Targeting and Membrane Biochemistry (CHEM 476, CHEM 676).
Reid NE, Ngou JS and Joyce PBM (2019) Schizosaccharomyces pombe contains separate CC- and A-adding tRNA nucleotidyltransferases. Biochem Biophys Res Commun. 508:785-790.
Leibovitch M, Reid NE, Victoria J, Hanic-Joyce PJ andJoyce PBM (2019) Analysis of the pathogenic I326T variant of human tRNAnucleotidyltransferase reveals reduced catalytic activity and thermal stability in vitro linked to a conformational change Biochim Biophys Acta Proteins Proteom 1867: 616-626.
Leibovitch M, Hanic-Joyce PJ and Joyce PBM (2018) In vitro studies of disease-linked variants of human tRNAnucleotidyltransferase reveal decreased thermal stability and altered catalyticactivity Biochim Biophys Acta Proteins Proteom 1867:616-626.
Chakraborty PK, Schmitz-Abe K, Kennedy EK, Mamady H, Naas T, Durie D, CampagnaDR, Lau A, Sendamarai AK, Wiseman DH, May A, Jolles S, Connor P, Powell C,Heeney MM, Giardina PJ, Klaassen RJ, Kannengiesser C, Thuret I, Thompson AA,Marques L, Hughes S, Bonney DK, Bottomley SS, Wynn RF, Laxer RM, Minniti CP,Moppett J, Bordon V, Geraghty M, Joyce PBM, Markianos K, Rudner AM, Holcik M,Fleming MD (2014) Mutations in TRNT1, encoding the CCA-adding enzyme, causecongenital sideroblastic anemia with B cell immunodeficiency, periodic fevers and developmental delay (SIFD). Blood 124:2867-2871.
My students in bold