Melissa K. Passarelli, Ph.D.
Photo by David Ward
The Pennsylvania State University (Ph.D.)
Union College (B.Sc.)
Analytical Chemistry for Biologist (Winter)
Imaging Mass Spectrometry (Summer)
Mass Spectrometry-based Intracellular Drug Measurements (FRQNT)
We are developing a multi-modal analytical approach that combined live-cell atomic force microscopy(AFM) and single-cell mass spectrometry (MS) to evaluate intracellular drug levels.
With this multi-modal approach, we will investigate the cellular uptake of pharmaceutical compounds and examine the biochemical effects at therapeutic and toxic levels.