Concordia University

http://www.concordia.ca/content/concordia/en/artsci/psychology/faculty.html

Shimon Amir, PhD

Professor, Psychology
Director, Center for Studies in Behavioral Neurobiology (CSBN)
Professor (Cross Appointment), Biology
Professor (Cross Appointment), Chemistry and Biochemistry

Office: L-SP 257-8 
Richard J. Renaud Science Complex,
7141 Sherbrooke W.
Phone: (514) 848-2424 ext. 2188
Email: Shimon.Amir@concordia.ca

Biography

Shimon Amir received his Ph.D. in Psychology from McGill University. After completing his postdoctoral training at the Center for Research on Drug Dependence, Concordia University, he joined the Department of Isotope Research and Neurobiology at the Weizmann Institute of Science, Rehovot, Israel, and was promoted to the rank of Associate Professor in 1986. In 1988 he joined the Department of Psychology and the Center for Studies in Behavioral Neurobiology at Concordia University and was promoted to the rank of Professor in 1991. He has been serving as Director of the Center for Studies in Behavioral Neurobiology since 2009. He was elected to the Board of Governors of Concordia in 2007 and has served as Vice-Chairman of the Board from 2011-2016. He is a Fellow of the Royal Society of Canada, Academy of Science; Fellow of the American Association for the advancement of Science; Fellow of the Canadian College of Neuropsychopharmacology; Fellow of the Association of Psychological Science; Member of the Provost Circle of Distinction; and Honorary Concordia University Research Chair.


Research

Circadian rhythms, Circadian clocks, Clock genes, Motivation, Stress, Glucocorticoids, Dopamine, mRNA translation control mechanisms, Animal models of psychiatric disorders

Overview: Circadian rhythms are daily oscillations in behavior, physiology and gene expression that help organisms adapt to recurring challenges and opportunities in their physical and social environment. In mammals, these rhythms are governed by a master clock located in the suprachiasmatic nucleus (SCN) and by subordinate clocks located elsewhere the brain and periphery. At a molecular level, the generation of circadian rhythms is based on autoregulatory transcriptional, translational, and posttranslational feedback loops driven by protein products of a small set of clock genes.

Members of my laboratory employ different animal models to study the nature, regulation, and function of circadian clocks in regions of the forebrain important in stress, motivation, and emotion.  Using molecular, anatomical, pharmacological, electrophysiological, and behavioral methods we study how the rhythms of expression of core clock genes and proteins within functionally-defined forebrain structures are synchronized; how these rhythms are affected by inputs from different regions of the brain; how they respond to environmental, behavioral, pharmacological, hormonal, and metabolic perturbations that disrupt homeostasis (e.g., changes in the external light cycle, stress, dopaminergic manipulations, treatment with drugs of abuse, glucocorticoids, restricted feeding); and, finally, how genetic and viral disruption of clock gene expression within specific brain regions influence behavior. In a second line of research we study modes and mechanisms of plasticity within the master SCN clock focusing on the role of translation control mechanisms (eIF4E, 4E-BP) and of conditioning/associative learning.

Funding

Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), Concordia University

Lab members

Nuria de Zavalia, PhD, Research Associate
Konrad Schoettner, PhD, Postdoctoral Fellow
Alex Gavrila, PhD candidate
Jeff Anyan, PhD candidate
Hanna Opiol, PhD candidate
Maxine Profitt, PhD candidate
Sara Ferraro, MSc Candidate
Miranda Benoit, MA candidate
Jory Goldsmith, Undergraduate
Pavel Solis, Undergraduate
Tara Delorme, Undergraduate
Camille Williams, Undergraduate
Margo Button, Undergraduate

From left, Maxine, Miranda, Margo, Jory, Camille, Hanna, Tara, Nuria, Konrad, Jeff, Pavel
D1 (red) and D2 (green) dopamine receptor-bearing neurons in the mouse bed nucleus of the stria terminalis
D1 (red) and D2 (green) dopamine receptors in the mouse central nucleus of the amygdala
Photo credit: Jory Goldsmith

Publications

Selected publications


Hood,S. and Amir, S. (2017) The aging clock: circadian rhythms and later life. Journal of Clinical Investigations 127, 437-446. 

Verwey,M., Dhir, S. and Amir, S. (2016) Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease. F1000Research5 (F1000 Faculty Rev):2062 (doi: 10.12688/f1000research.9180.1)

Cao, R., Gkogkas, C. G.,De Zavalia, N., Blum, I., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, S.,Storch,K.F., Liu, A.C., Amir, S. and Sonenberg, N. (2015) Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience 18, 855-862.  DOI: 10.1038/nn.4010 [PubMed]

Cao R, Robinson B, Xu H, GkogkasC, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N (2013) Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron 79:712-724. [PubMed] [Full]

Hood S, Cassidy P, Cossette MP,Weigl Y, Verwey M, Robinson B, Stewart J, Amir S (2010) Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors. J Neurosci 30:14046-14058. [PubMed] [Full]

Amir S, Stewart J (2009) Motivational modulation of rhythms of the expression of the clock protein PER2in the limbic forebrain. Biol Psychiatry 65:829-834. [PubMed] [Full]

Verwey M, Amir S (2009) Food-entrainable circadian oscillators in the brain. Eur J Neurosci30:1650-1657.[PubMed] [Full]

Segall LA, Perrin JS, Walker CD, Stewart J, Amir S (2006) Glucocorticoid rhythms control the rhythm of expression of the clock protein, Period2, in oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in rats. Neuroscience140:753-757. [PubMed] [Full]

Perrin JS, Segall LA, Harbour VL, Woodside B, Amir S (2006) The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle. Proc Natl Acad Sci U S A103:5591-5596. [PubMed][Full]

Lamont EW, Robinson B, Stewart J, Amir S (2005) The central and basolateral nuclei of the amygdala exhibit opposite diurnal rhythms of expression of the clock protein Period2. Proc Natl Acad Sci U S A 102:4180-4184. [PubMed] [Full]

Amir S, Lamont EW, Robinson B,Stewart J (2004) A circadian rhythm in the expression of PERIOD2 protein reveals a novel SCN-controlled oscillator in the oval nucleus of the bed nucleus of the stria terminalis. J Neurosci 24:781-790. [PubMed] [Full]

Edelstein K, Amir S (1999) The role of the intergeniculate leaflet in entrainment of circadian rhythms to a skeleton photoperiod. J Neurosci 19:372-380. [PubMed] [Full]

Amir S, Stewart J (1996) Resetting of the circadian clock by a conditioned stimulus. Nature 379:542-545.[PubMed] [Full]

Complete publication list

Hood, S. and Amir, S. (2017) Neurodegeneration and the circadian clock. Frontiers in Aging Neuroscience 9, 170. doi:10.3389/fnagi.2017.00170


Gavrila AM, Hood S, Robinson B, Amir S (2017) Effects of bilateral anterioragranular insula lesions on food anticipatory activity in rats.  PLoS ONE 12(6): e0179370. 

https://doi.org/10.1371/journal.pone.0179370


Frederick,A., Goldsmith, J., de Zavalia, N. and Amir,S. Mapping the co-localization of the circadian proteins PER2 and BMAL1with enkephalin and substance P throughout the rodent forebrain. PLoS ONE 12(4): e0176279. https://doi.org/10.1371/journal.pone.0176279

Opiol, H., de Zavalia, N.,Delorme, T., Solis, P., Rutherford, S., Shalev, U. and Amir, S. Exploring the role of locomotor sensitization in the circadian food entrainment pathway. PLoS ONE 12(3):e0174113.

Hood, S. and Amir,S. (2017) The aging clock: circadian rhythms and later life. Journal of Clinical Investigations 127, 437-446.

Verwey, M., Dhir, S. and Amir, S. (2016) Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease.F1000Research 5 (F1000 Faculty Rev):2062 (doi: 10.12688/f1000research.9180.1)

Verwey,M. and Amir, S. (2016) From genes to chronotypes: The influence of circadian clock genes on our daily patterns of sleep and wakefulness. Annals of Translational Medicine 4, 184. doi: 10.21037/atm.2016.04.19.

Al-Safadi,S., Branchaud, M., Rutheford, S. and Amir, S.  (2015) Glucocorticoids and stress-induced changes in the expression of the circadian clock protein PERIOD1in the rat forebrain. PLoS One10(6): e0130085.doi:10.1371/journal.pone.0130085.

Cao, R., Gkogkas, C. G., de Zavalia, N., Blum, I., Yanagiya, A., Tsukumo, Y., Xu, H., Lee, S., Storch, K.F., Liu, A.C., Amir, S. and Sonenberg, N. (2015) Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience 18, 855-862.  DOI: 10.1038/nn.4010 [PubMed]

Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R (2014) Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat. Frontiers in Systems Neuroscience 8:145 [Abstract] [Content]

Al-Safadi, S., Al-Safadi, A., Branchaud, M., Rutheford, S.,Dayanandan, A., Robinson, B. and Amir, S. (2014) Stress-induced changes in the expression of the clock protein PERIOD1 in the rat limbic forebrain and hypothalamus: role of stress type, time of day,and predictability. PLoS ONE, 9(10): e111166. doi:10.1371/journal.pone.0111166. [PubMed]

Harbour VL, Weigl Y, Robinson B, Amir S (2014) Phase differences in expression of circadian clock genes in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleus in the rat. PLoS ONE 9:e103309. [PubMed] [Content]

Harbour VL, Weigl Y, Robinson B, Amir S (2013) Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day. PLoS ONE 8:e76391. [PubMed] [Content]

Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N (2013) Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron 79:712-724. [PubMed] [Content]

Weigl Y, Harbour VL, Robinson B, Dufresne L, Amir S (2013) Peripheral circadian clocks—a conserved phenotype? Chronobiol Int 30:559-576. [PubMed] [Content]

Verwey M, Robinson B, Amir S (2013) Recording and analysis of circadian rhythms in running-wheel activity in rodents. J Vis Exp 71:e50186. [PubMed] [Content] [Video]

Verwey M, Amir S (2012) Variable restricted feeding disrupts the daily oscillations of Period2 expression in the limbic forebrain and dorsal striatum in rats. J Mol Neurosci 46:258-264. [PubMed] [Content]

Verwey M, Amir S (2011) Nucleus-specific effects of meal duration on daily profiles of Period1 and Period2 protein expression in rats housed under restricted feeding. Neuroscience 192:304-311. [PubMed] [Content]

Hood S, Cassidy P, Mathewson S, Stewart J, Amir S (2011) Daily morphine injection and withdrawal disrupt 24-h wheel running and PERIOD2 expression patterns in the rat limbic forebrain. Neuroscience 186:65-75. [PubMed] [Content]

Gravotta L, Gavrila AM, Hood S, Amir S (2011) Global depletion of dopamine using intracerebroventricular 6-hydroxydopamine injection disrupts normal circadian wheel-running patterns and PERIOD2 expression in the rat forebrain. J Mol Neurosci 45:162–171. [PubMed] [Content]

Harbour VL, Robinson B, Amir S (2011) Variations in daily expression of the circadian clock protein, PER2, in the rat limbic forebrain during stable entrainment to a long light cycle. J Mol Neurosci 45:154–161. [PubMed] [Content]

Hood S, Cassidy P, Cossette MP, Weigl Y, Verwey M, Robinson B, Stewart J, Amir S (2010) Endogenous dopamine regulates the rhythm of expression of the clock protein PER2 in the rat dorsal striatum via daily activation of D2 dopamine receptors. J Neurosci 30:14046-14058. [PubMed] [Content]

Segall LA, Amir S (2010) Exogenous corticosterone induces the expression of the clock protein, PERIOD2, in the oval nucleus of the bed nucleus of the stria terminalis and the central nucleus of the amygdala of adrenalectomized and intact rats. J Mol Neurosci 42:176-182. [PubMed] [Content]

Segall LA, Amir S (2010) Glucocorticoid regulation of clock gene expression in the mammalian limbic forebrain. J Mol Neurosci 42:168-175. [PubMed] [Content]

Abizaid A, Amir S (2010) Eating and Appetite. In: Stolerman IP (ed) Encyclopedia of psychopharmacology, part 5. Springer, pp 447-450. [Content]

Lamont EW, Amir S (2010) Circadian and ultradian clocks/rhythms. In: Koob GF, Le Moal M, Thompson RF (eds) Encyclopedia of behavioral neuroscience, vol 1. Academic Press, Oxford, pp 257-261. [Abstract]

Verwey M, Amir S (2009) Food-entrainable circadian oscillators in the brain. Eur J Neurosci 30:1650-1657. [PubMed] [Content]

Amir S, Stewart J (2009) Behavioral and hormonal regulation of expression of the clock protein, PER2, in the central extended amygdala. Prog Neuropsychopharmacol Biol Psychiatry 33:1321-1328. [PubMed] [Content]

Lamont EW, Amir S (2009) Masking (positive/negative). In: Binder MD, Hirokawa N, Windhorst U (eds) Encyclopedia of Neuroscience. Springer, pp 2241-2242. [Content]

Segall LA, Milet A, Tronche F, Amir S (2009) Brain glucocorticoid receptors are necessary for the rhythmic expression of the clock protein, PERIOD2, in the central extended amygdala in mice. Neurosci Lett 457:58-60. [PubMed] [Content]

Verwey M, Lam GY, Amir S (2009) Circadian rhythms of PERIOD1 expression in the dorsomedial hypothalamic nucleus in the absence of entrained food-anticipatory activity rhythms in rats. Eur J Neurosci 29:2217-2222. [PubMed] [Content]

Amir S, Stewart J (2009) Motivational modulation of rhythms of the expression of the clock protein PER2 in the limbic forebrain. Biol Psychiatry 65:829-834. [PubMed] [Content]

Segall LA, Verwey M, Amir S (2008) Timed restricted feeding restores the rhythms of expression of the clock protein, Period2, in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in adrenalectomized rats. Neuroscience 157:52-56. [PubMed] [Content]

Verwey M, Khoja Z, Stewart J, Amir S (2008) Region-specific modulation of PER2 expression in the limbic forebrain and hypothalamus by nighttime restricted feeding in rats. Neurosci Lett 440:54-58. [PubMed] [Content]

Gavrila AM, Robinson B, Hoy J, Stewart J, Bhargava A, Amir S (2008) Double-stranded RNA-mediated suppression of Period2 expression in the suprachiasmatic nucleus disrupts circadian locomotor activity in rats. Neuroscience 154:409-414. [PubMed] [Content]

Rodaros D, Caruana DA, Amir S, Stewart J (2007) Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area. Neuroscience 150:8-13. [PubMed] [Content]

Verwey M, Khoja Z, Stewart J, Amir S (2007) Differential regulation of the expression of Period2 protein in the limbic forebrain and dorsomedial hypothalamus by daily limited access to highly palatable food in food-deprived and free-fed rats. Neuroscience 147:277-285. [PubMed] [Content]

Waddington Lamont E, Harbour VL, Barry-Shaw J, Renteria Diaz L, Robinson B, Stewart J, Amir S (2007) Restricted access to food, but not sucrose, saccharine, or salt, synchronizes the expression of Period2 protein in the limbic forebrain. Neuroscience 144:402-411. [PubMed] [Content]

Amir S, Robinson B (2006) Thyroidectomy alters the daily pattern of expression of the clock protein, PER2, in the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in rats. Neurosci Lett 407:254-257. [PubMed] [Content]

Segall LA, Perrin JS, Walker CD, Stewart J, Amir S (2006) Glucocorticoid rhythms control the rhythm of expression of the clock protein, Period2, in oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala in rats. Neuroscience 140:753-757. [PubMed] [Content]

Perrin JS, Segall LA, Harbour VL, Woodside B, Amir S (2006) The expression of the clock protein PER2 in the limbic forebrain is modulated by the estrous cycle. Proc Natl Acad Sci U S A 103:5591-5596. [PubMed] [Content]

Amir S, Harbour VL, Robinson B (2006) Pinealectomy does not affect diurnal PER2 expression in the rat limbic forebrain. Neurosci Lett 399:147-150. [PubMed] [Content]

Lamont EW, Diaz LR, Barry-Shaw J, Stewart J, Amir S (2005) Daily restricted feeding rescues a rhythm of period2 expression in the arrhythmic suprachiasmatic nucleus. Neuroscience 132:245-248. [PubMed] [Content]

Lamont EW, Robinson B, Stewart J, Amir S (2005) The central and basolateral nuclei of the amygdala exhibit opposite diurnal rhythms of expression of the clock protein Period2. Proc Natl Acad Sci U S A 102:4180-4184. [PubMed] [Content]

Amir S, Lamont EW, Robinson B, Stewart J (2004) A circadian rhythm in the expression of PERIOD2 protein reveals a novel SCN-controlled oscillator in the oval nucleus of the bed nucleus of the stria terminalis. J Neurosci 24:781-790. [PubMed] [Content]

Beaule C, Barry-Shaw J, Amir S (2004) Fos expression in the suprachiasmatic nucleus during photic entrainment of circadian rhythms in retinally damaged rats. J Mol Neurosci 22:223-230. [PubMed] [Content]

Beaule C, Amir S (2003) The eyes suppress a circadian rhythm of FOS expression in the suprachiasmatic nucleus in the absence of light. Neuroscience 121:253-257. [PubMed] [Content]

Beaule C, Houle LM, Amir S (2003) Expression profiles of PER2 immunoreactivity within the shell and core regions of the rat suprachiasmatic nucleus: lack of effect of photic entrainment and disruption by constant light. J Mol Neurosci 21:133-147. [PubMed] [Content]

Beaule C, Robinson B, Lamont EW, Amir S (2003) Melanopsin in the circadian timing system. J Mol Neurosci 21:73-89. [PubMed] [Content]

Popeski N, Amir S, Diorio J, Woodside B (2003) Prolactin and oxytocin interaction in the paraventricular and supraoptic nuclei: effects on oxytocin mRNA and nitric oxide synthase. J Neuroendocrinol 15:687-696. [PubMed] [Content]

Amir S, Beaule C, Arvanitogiannis A, Stewart J (2002) Modes of plasticity within the mammalian circadian system. Prog Brain Res 138:191-203. [PubMed] [Abstract] [Content]

Beaule C, Amir S (2002) Effect of 192 IgG-saporin on circadian activity rhythms, expression of P75 neurotrophin receptors, calbindin-D28K, and light-induced Fos in the suprachiasmatic nucleus in rats. Exp Neurol 176:377-389. [PubMed] [Content]

Arvanitogiannis A, Amir S (2001) A novel, associative process modulating photic resetting of the circadian clock. Neuroscience 104:615-618. [PubMed] [Content]

Beaule C, Amir S (2001) Photic regulation of circadian rhythms and the expression of p75 neurotrophin receptor immunoreactivity in the suprachiasmatic nucleus in rats. Brain Res 894:301-306. [PubMed] [Content]

Beaule C, Arvanitogiannis A, Amir S (2001) Light suppresses Fos expression in the shell region of the suprachiasmatic nucleus at dusk and dawn: implications for photic entrainment of circadian rhythms. Neuroscience 106:249-254. [PubMed] [Content]

Arvanitogiannis A, Sullivan J, Amir S (2000) Time acts as a conditioned stimulus to control behavioral sensitization to amphetamine in rats. Neuroscience 101:1-3. [PubMed] [Content]

Arvanitogiannis A, Robinson B, Beaule C, Amir S (2000) Calbindin-D28k immunoreactivity in the suprachiasmatic nucleus and the circadian response to constant light in the rat. Neuroscience 99:397-401. [PubMed] [Content]

Arvanitogiannis A, Stewart J, Amir S (2000) Conditioned stimulus control in the circadian system: two tales tell one story. J Biol Rhythms 15:292-293; discussion 294-295. [PubMed] [Content]

Edelstein K, Beaule C, D'Abramo R, Amir S (2000) Expression profiles of JunB and c-Fos proteins in the rat circadian system. Brain Res 870:54-65. [PubMed] [Content]

Funk D, Amir S (2000) Circadian modulation of fos responses to odor of the red fox, a rodent predator, in the rat olfactory system. Brain Res 866:262-267. [PubMed] [Content]

Funk D, Amir S (2000) Enhanced fos expression within the primary olfactory and limbic pathways induced by an aversive conditioned odor stimulus. Neuroscience 98:403-406 [PubMed] [Content]

Woodside B, Amir S (2000) Nitric oxide signaling in the hypothalamus. In: Steinbusch HWM, De Vente J, Vincent SR (eds) Handbook of chemical neuroanatomy, vol 17: Functional neuroanatomy of the nitric oxide system. Elsevier, pp 147-176. [Abstract]

Arvanitogiannis A, Amir S (1999) Conditioned stimulus control in the rat circadian system depends on clock resetting during conditioning. Behav Neurosci 113:1297-1300. [PubMed] [Abstract]

Funk D, Amir S (1999) Conditioned fear attenuates light-induced suppression of melatonin release in rats. Physiol Behav 67:623-626. [PubMed] [Content]

Amir S, Cain S, Sullivan J, Robinson B, Stewart J (1999) In rats, odor-induced Fos in the olfactory pathways depends on the phase of the circadian clock. Neurosci Lett 272:175-178. [PubMed] [Content]

Amir S, Cain S, Sullivan J, Robinson B, Stewart J (1999) Olfactory stimulation enhances light-induced phase shifts in free-running activity rhythms and Fos expression in the suprachiasmatic nucleus. Neuroscience 92:1165-1170. [PubMed] [Content]

Goodwin FL, Amir S, Amit Z (1999) Environmental lighting has a selective influence on ethanol intake in rats. Physiol Behav 66:323-328. [PubMed] [Content]

Edelstein K, Amir S (1999) The intergeniculate leaflet does not mediate the disruptive effects of constant light on circadian rhythms in the rat. Neuroscience 90:1093-1101. [PubMed] [Content]

Amir S, Stewart J (1999) The effectiveness of light on the circadian clock is linked to its emotional value. Neuroscience 88:339-345. [PubMed] [Content]

Amir S, Stewart J (1999) Conditioned and unconditioned aversive stimuli enhance light-induced fos expression in the primary visual cortex. Neuroscience 89:323-327 [PubMed] [Content]

Arvanitogiannis A, Amir S (1999) Resetting the rat circadian clock by ultra-short light flashes. Neurosci Lett 261:159-162. [PubMed] [Content]

Beaule C, Amir S (1999) Photic entrainment and induction of immediate-early genes within the rat circadian system. Brain Res 821:95-100. [PubMed] [Content]

Edelstein K, Amir S (1999) The role of the intergeniculate leaflet in entrainment of circadian rhythms to a skeleton photoperiod. J Neurosci 19:372-380. [PubMed] [Content]

Popeski N, Amir S, Woodside B (1999) Changes in NADPH-d staining in the paraventricular and supraoptic nuclei during pregnancy and lactation in rats: role of ovarian steroids and oxytocin. J Neuroendocrinol 11:53-61. [PubMed] [Content]

Amir S, Stewart J (1998) Conditioned fear suppresses light-induced resetting of the circadian clock. Neuroscience 86:345-351. [PubMed] [Content]

Edelstein K, Amir S (1998) Glutamatergic antagonists do not attenuate light-induced fos protein in rat intergeniculate leaflet. Brain Res 810:264-268. [PubMed] [Content]

Amir S, Stewart J (1998) Conditioning in the circadian system. Chronobiol Int 15:447-456. [PubMed] [Content]

Amir S, Robinson B, Ratovitski T, Rea MA, Stewart J, Simantov R (1998) A role for serotonin in the circadian system revealed by the distribution of serotonin transporter and light-induced Fos immunoreactivity in the suprachiasmatic nucleus and intergeniculate leaflet. Neuroscience 84:1059-1073. [PubMed] [Content]

Amir S, Stewart J (1998) Induction of Fos expression in the circadian system by unsignaled light is attenuated as a result of previous experience with signaled light: a role for Pavlovian conditioning. Neuroscience 83:657-661. [PubMed] [Content]

Amir S, Edelstein K (1997) A blocker of nitric oxide synthase, NG-nitro-L-arginine methyl ester, attenuates light-induced Fos protein expression in rat suprachiasmatic nucleus. Neurosci Lett 224:29-32. [PubMed] [Content]

Amir S, Rackover M, Funk D (1997) Blockers of nitric oxide synthase inhibit stress activation of c-fos expression in neurons of the hypothalamic paraventricular nucleus in the rat. Neuroscience 77:623-627. [PubMed] [Content]

Woodside B, Amir S (1997) Lactation reduces Fos induction in the paraventricular and supraoptic nuclei of the hypothalamus after urethane administration in rats. Brain Res 752:319-323. [PubMed] [Content]

Edelstein K, Amir S (1996) Constant light induces persistent Fos expression in rat intergeniculate leaflet. Brain Res 731:221-225. [PubMed] [Content]

Amir S, Robinson B (1996) Fos expression in rat visual cortex induced by ocular input of ultraviolet light. Brain Res 716:213-218. [PubMed] [Content]

Amir S, Stewart J (1996) Resetting of the circadian clock by a conditioned stimulus. Nature 379:542-545. [PubMed] [Content]

Woodside B, Amir S (1996) Reproductive state changes NADPH-diaphorase staining in the paraventricular and supraoptic nuclei of female rats. Brain Res 739:339-342. [PubMed] [Content]

Amir S (1995) Nitric oxide signalling in the hypothalamus. In: Vincent SR (ed) Nitric oxide in the nervous system. Academic Press, pp. 151-162. [Abstract]

Amir S, Robinson B, Edelstein K (1995) Distribution of NADPH-diaphorase staining and light-induced Fos expression in the rat suprachiasmatic nucleus region supports a role for nitric oxide in the circadian system. Neuroscience 69:545-555. [PubMed] [Content]

Amir S, Robinson B (1995) Ultraviolet light entrains rodent suprachiasmatic nucleus pacemaker. Neuroscience 69:1005-1011. [PubMed] [Content]

Edelstein K, Amir S (1995) Non-photic manipulations induce expression of Fos protein in the suprachiasmatic nucleus and intergeniculate leaflet in the rat. Brain Res 690:254-258. [PubMed] [Content]

Edelstein K, Pfaus JG, Rusak B, Amir S (1995) Neonatal monosodium glutamate treatment prevents effects of constant light on circadian temperature rhythms of adult rats. Brain Res 675:135-142. [PubMed] [Content]

Rotzinger S, Aragon CM, Rogan F, Amir S, Amit Z (1995) The nitric oxide synthase inhibitor NW-nitro-L-arginine methylester attenuates brain catalase activity in vitro. Life Sci 56:1321-1324. [PubMed] [Content]

Woodside B, Robinson B, Amir S (1995) Induction of Fos protein in a model of closed head injury in rats. Brain Res 690:48-54. [PubMed] [Content]

Amir S (1994) N-Methyl-D-aspartate receptor-mediated signaling in the supraoptic nucleus involves activation of a nitric oxide-dependent pathway. Brain Res 645:330-334. [PubMed] [Abstract] [Content]

Amir S, Robinson B, Woodside B (1994) Induction of Fos protein in the piriform cortex after brain injury in pentobarbital-anaesthetized rats: lack of effect of lactation. Brain Res 652:341-345. [PubMed] [Abstract] [Content]

Dib B, Rompre PP, Amir S, Shizgal P (1994) Thermogenesis in brown adipose tissue is activated by electrical stimulation of the rat dorsal raphe nucleus. Brain Res 650:149-152. [PubMed] [Abstract] [Content]

Stewart J, Deschamps SE, Amir S (1994) Inhibition of nitric oxide synthase does not block the development of sensitization to the behavioral activating effects of amphetamine. Brain Res 641:141-144. [PubMed] [Abstract] [Content]

Bhatnagar S, Meaney MJ, Amir S (1993) The effects of prostaglandin E2 injected into the paraventricular nucleus of the hypothalamus on brown adipose tissue thermogenesis in spontaneously hypertensive rats. Brain Res 613:285-287. [PubMed] [Abstract] [Content]

Amir S (1992) Blocking NMDA receptors or nitric oxide production disrupts light transmission to the suprachiasmatic nucleus. Brain Res 586:336-339. [PubMed] [Abstract] [Content]

Amir S, English AM (1991) An inhibitor of nitric oxide production, NG-nitro-L-arginine-methyl ester, improves survival in anaphylactic shock. Eur J Pharmacol 203:125-127. [PubMed] [Abstract] [Content]

Amir S, De Blasio E (1991) Activation of brown adipose tissue thermogenesis by chemical stimulation of the hypothalamic supraoptic nucleus. Brain Res 563:349-352. [PubMed] [Abstract] [Content]

Amir S, De Blasio E, English AM (1991) NG-monomethyl-L-arginine co-injection attenuates the thermogenic and hyperthermic effects of E2 prostaglandin microinjection into the anterior hypothalamic preoptic area in rats. Brain Res 556:157-160. [PubMed] [Content]

Amir S (1990) Activation of brown adipose tissue thermogenesis by chemical stimulation of the posterior hypothalamus. Brain Res 534:303-308. [PubMed] [Abstract] [Content]

Amir S (1990) Intra-ventromedial hypothalamic injection of glutamate stimulates brown adipose tissue thermogenesis in the rat. Brain Res 511:341-344. [PubMed] [Abstract] [Content]

Amir S (1990) Stimulation of the paraventricular nucleus with glutamate activates interscapular brown adipose tissue thermogenesis in rats. Brain Res 508:152-155. [PubMed] [Abstract] [Content]

Amir S, Pollock R (1990) Counterregulation of stress-induced hyperglycemia by thyrotropin-releasing hormone. In: Puglisi-Allegra S, Oliverio A (eds) Psychobiology of Stress. Springer, pp 143-150. [Content]

Amir S, Schiavetto A (1990) Injection of prostaglandin E2 into the anterior hypothalamic preoptic area activates brown adipose tissue thermogenesis in the rat. Brain Res 528:138-142. [PubMed] [Abstract] [Content]

Amir S, Schiavetto A, Pollock R (1990) Insulin co-injection suppresses the thermogenic response to glutamate microinjection into the VMH in rats. Brain Res 527:326-329. [PubMed] [Abstract] [Content]

Dymshitz J, Malach R, Amir S, Simantov R (1990) Factors regulating the expression of acetylcholinesterase-containing neurons in striatal cultures: effects of chemical depolarization. Brain Res 532:131-139. [PubMed] [Abstract] [Content]

Shechter Y, Meyerovitch J, Farfel Z, Sack J, Bruck R, Bar-Meir S, Amir S, Degani H, Karlish SJ (1990) Insulin mimetic effects of vanadium. In: Chasteen ND (ed) Vanadium in in biological systems: physiology and biochemistry. Springer, pp 129-142.

Amit Z, Amir S (1990) Introduction. Neurosci Biobehav Rev 14:521. [Abstract]

Amir S (1989) Retinohypothalamic tract stimulation activates thermogenesis in brown adipose tissue in the rat. Brain Res 503:163-166. [PubMed] [Abstract] [Content]

Amir S, Shizgal P, Rompre PP (1989) Glutamate injection into the suprachiasmatic nucleus stimulates brown fat thermogenesis in the rat. Brain Res 498:140-144. [PubMed] [Abstract] [Content]

Amir S, Lagiorgia M, Pollock R (1989) Intra-ventromedial hypothalamic injection of insulin suppresses brown fat thermogenesis in the anaesthetized rat. Brain Res 480:340-343. [PubMed] [Abstract] [Content]

Amir S, Pollock R, Lagiorgia M (1989) Intra-hypothalamic injection of thyrotropin-releasing hormone suppresses brown fat thermogenesis in the anaesthetized rat. Brain Res 478:361-364. [PubMed] [Abstract] [Content]

Meyerovitch J, Shechter Y, Amir S (1989) Vanadate stimulates in vivo glucose uptake in brain and arrests food intake and body weight gain in rats. Physiol Behav 45:1113-1116. [PubMed] [Abstract] [Content]

Shechter Y, Amir S, Meyerovitch J (1988) The insulin-like metabolic effects of vanadate: possible implications to the future care of diabetes (Review). Diabetes Nutr Metab 1:1-5.

Amir S, Shechter Y (1988) Glucose transport. Nature 336:528. [PubMed] [Content]

Amir S (1988) Thyrotropin-releasing hormone (TRH): insulin-like action on glucoregulation. Biochem Pharmacol 37:4245-4251. [PubMed] [Abstract] [Content]

Amir S, Jackson IM (1988) Immunological blockade of endogenous thyrotropin-releasing hormone impairs recovery from hyperglycemia in mice. Brain Res 462:160-162. [PubMed] [Abstract] [Content]

Amir S (1988) Thyrotropin-releasing hormone (TRH) blocks glucagon-induced hyperglycemia in mice: dissociation of the antihyperglycemic and pituitary actions of TRH. Brain Res 455:201-203. [PubMed] [Abstract] [Content]

Amir S (1988) TPA (12-O-tetradecanoylphorbol-13-acetate) enhances the central hypoglycemic action of thyrotropin-releasing hormone in mice. Brain Res 450:369-372. [PubMed] [Abstract] [Content]

Amir S (1988) Aging blocks the thermoregulatory action of thyrotropin-releasing hormone in anaesthetized rats. Brain Res 440:181-184. [PubMed] [Abstract] [Content]

Amir S (1988) Anaphylactic shock: catecholamine actions in the responses to opioid antagonists. Prog Clin Biol Res 264:265-274. [PubMed]

Amir S, Shechter Y (1988) Apparent involvement of protein kinase C in the central glucoregulatory action of insulin. Brain Res 450:272-279. [PubMed] [Abstract] [Content]

Amir S, Butler PD (1988) Thyrotropin-releasing hormone blocks neurally-mediated hyperglycemia through central action. Peptides 9:31-35. [PubMed] [Abstract] [Content]

Amir S, Rivkind AI (1988) Prevention of clonidine-stimulated hyperglycemia by thyrotropin-releasing hormone. Peptides 9:527-531. [PubMed] [Abstract] [Content]

Dymshitz J, Amir S (1988) Opposite effects of restraint on morphine analgesia and naloxone-induced jumping. Pharmacol Biochem Behav 30:905-910. [PubMed] [Abstract] [Content]

Shechter Y, Meyerovitch J, Amir S (1988) The use of post-binding agents in studying insulin action and its relation to experimental diabetes. Biochem Pharmacol 37:1891-1896. [PubMed] [Abstract] [Content]

Malcolm DS, Zaloga GP, Willey SC, Amir S, Holaday JW (1988) Naloxone potentiates epinephrine's pressor actions in endotoxemic rats. Circ Shock 25:259-265. [PubMed]

Amir S, Harel M, Rivkind AI (1987) Thyrotropin-releasing hormone potently reverses epinephrine-stimulated hyperglycemia in mice. Brain Res 435:112-122. [PubMed] [Abstract] [Content]

Amir S, Meyerovitch J, Shechter Y (1987) Vanadate ions: central nervous system action on glucoregulation. Brain Res 419:392-396. [PubMed] [Abstract] [Content]

Amir S, Shechter Y (1987) Centrally mediated hypoglycemic effect of insulin: apparent involvement of specific insulin receptors. Brain Res 418:152-156. [PubMed] [Abstract] [Content]

Amir S, Sasson S, Kaiser N, Meyerovitch J, Shechter Y (1987) Polymyxin B is an inhibitor of insulin-induced hypoglycemia in the whole animal model. Studies on the mode of inhibitory action. J Biol Chem 262:6663-6667. [PubMed] [Content]

Amir S (1986) Endorphins contribute to the loss of glucose homeostasis in anaphylactic shock. NIDA Res Monogr 75:375-378. [PubMed] [Content]

Amir S (1986) Central glucagon-induced hyperglycemia is mediated by combined activation of the adrenal medulla and sympathetic nerve endings. Physiol Behav 37:563-566. [PubMed] [Abstract] [Content]

Amir S (1986) Catalepsy induced by body pinch: relation to stress-induced analgesia. Ann N Y Acad Sci 467:226-237. [PubMed] [Content]

Malcolm DS, Amir S, Holaday JW (1986) Central glucagon antagonizes morphine- and stress-induced antinociception in the mouse. NIDA Res Monogr 75:371-374. [PubMed] [Content]

Amir S, Rivkind AI, Harel M (1985) Central thyrotropin-releasing hormone elicits systemic hypoglycemia in mice. Brain Res 344:387-391. [PubMed] [Abstract] [Content]

Amir S, Harel M (1985) Systemic hypoglycemia following central injection of endotoxin in mice. Brain Res 339:382-385. [PubMed] [Abstract] [Content]

Amir S, Shechter Y (1985) Polymyxin B is a potent inhibitor of insulin hypoglycemia in mice. Eur J Pharmacol 110:283-285. [PubMed] [Abstract] [Content]

Amir S, van Ree JM (1985) Beneficial effect of gamma-endorphin-type peptides in anaphylactic shock. Brain Res 329:329-333. [PubMed] [Abstract] [Content]

Drago F, Amir S, Continella G, Concetta Alloro M, Scapagnini U (1985) Effects of endogenous hyperprolactinemia on adaptive responses to stress. In: Macleod RM, Thorner MO, Scapagnini U (eds) Prolactin: basic and clinical aspects. Fidia Research Series, Albano Terme, Vol 1, pp 609-614.

Amir S (1984) Anti-anaphylactic action in the mouse of thyrotropin-releasing hormone (TRH) is mediated through beta 1-adrenoceptive effectors. Neurosci Lett 46:127-130. [PubMed] [Abstract] [Content]

Amir S (1984) Opiate antagonists reverse the hypoactivity associated with systemic anaphylaxis in mice. Pharmacol Biochem Behav 20:483-485. [PubMed] [Abstract] [Content]

Amir S (1984) Beneficial effect of i.c.v. naloxone in anaphylactic shock is mediated through peripheral beta-adrenoceptive mechanisms. Brain Res 290:191-194. [PubMed] [Abstract] [Content]

Amir S, Harel M, Schachar A (1984) Thyrotropin-releasing hormone (TRH) improves survival in anaphylactic shock: a central effect mediated by the sympatho-adrenomedullary beta-adrenoceptive system. Brain Res 298:219-224. [PubMed] [Abstract] [Content]

Drago F, Amir S (1984) Effects of hyperprolactinaemia on core temperature of the rat. Brain Res Bull 12:355-358. [PubMed] [Abstract] [Content]

Amir S (1984) Naloxone improves, and morphine exacerbates, experimental shock induced by release of endogenous histamine by compound 48/80. Brain Res 297:187-190. "http://www.ncbi.nlm.nih.gov/pubmed/6722534" target="_top">[PubMed] [Content]

Amir S (1983) Proanaphylactic action of morphine is mediated through a central cholinergic mechanism. Eur J Pharmacol 95:117-119. [PubMed] [Abstract] [Content]

Amir S (1983) Morphine exacerbates anaphylactic shock in mice by stimulating central opiate receptors. Neurosci Lett 40:169-174. [PubMed] [Abstract]

Amir S (1983) Antianaphylactic effect of naloxone in mice is mediated by increased central sympathetic outflow to sympathetic nerve endings and adrenal medulla. Brain Res 274:180-183. [PubMed] "http://dx.doi.org/10.1016/0006-8993(83)90537-1" target="_top">[Abstract]

Amir S, Harel M (1983) Role of endorphins in endotoxin-induced hyperglycaemia in mice. Neuropharmacology 22:1117-1119. [PubMed] [Abstract] [Content]

Amir S, Harel M (1983) Endorphins in endotoxin-induced hyperglycemia in mice. Arch Toxicol Suppl 6:261-265. [PubMed]

Simantov R, Amir S (1983) Regulation of opiate receptors in mouse brain: arcuate nuclear lesion induces receptor up-regulation and supersensitivity to opiates. Brain Res 262:168-171. [PubMed] [Abstract] [Content]

Amir S (1982) Opiate antagonists improve survival in anaphylactic shock. Eur J Pharmacol 80:161-162. [PubMed] [Abstract] [Content]

Amir S (1982) Involvement of endogenous opioids with forced swimming-induced immobility in mice. Physiol Behav 28:249-251. [PubMed] [Abstract] [Content]

Amir S, Bernstein M (1982) Endogenous opioids interact in stress-induced hyperglycemia in mice. Physiol Behav 28:575-577. [PubMed] [Abstract] [Content]

Amir S, Davis L (1982) Protective effect of neonatal monosodium glutamate-induced arcuate nucleus lesions in anaphylactic shock. Eur J Pharmacol 84:237-238. [PubMed] [Abstract] [Content]

Amir S (1981) Effects of ACTH on pain responsiveness in mice: interaction with morphine. Neuropharmacology 20:959-962. [PubMed] [Abstract] [Content]

Amir S (1981) Behavioral response of the genetically obese (ob/ob) mouse to heat stress: effects of naloxone and prior exposure to immobilization stress. Physiol Behav 27:249-253. [PubMed] [Abstract] [Content]

Amir S, Simantov R (1981) Chronic lithium administration alters the interaction between opiate antagonists and opiate receptors in vivo. Neuropharmacology 20:587-591. [PubMed] [Abstract] [Content]

Amir S, Amit Z, Brown ZW (1981) A simple and adjustable restraining apparatus for mice. Physiol Behav 26:335-336. [PubMed] [Abstract] [Content]

Amir S, Brown ZW, Amit Z, Ornstein K (1981) Body pinch induces long lasting cataleptic like immobility in mice: behavioral characterization and the effect of naloxone. Life Sci 28:1189-1194. [PubMed] [Abstract] [Content]

Amir S, Amit Z, Brown ZW (1981) Stress, endorphins and psychosis. A hypothesis. Mod Probl Pharmacopsychiatry 17:192-201. [PubMed]

Ornstein K, Amir S (1981) Pinch-induced catalepsy in mice. J Comp Physiol Psychol 95:827-835. [PubMed] [Content]

Amir S, Galina ZH, Blair R, Brown ZW, Amit Z (1980) Opiate receptors may mediate the suppressive but not the excitatory action of ACTH on motor activity in rats. Eur J Pharmacol 66:307-313. [PubMed] [Abstract] [Content]

Amir S, Brown ZW, Amit Z (1980) The role of endorphins in stress: evidence and speculations. Neurosci Biobehav Rev 4:77-86. [PubMed] [Abstract] [Content]

Amit Z, Brown ZW, Rockman GE, Smith B, Amir S (1980) Acetaldehyde: a positive reinforcer mediating ethanol consumption. Adv Exp Med Biol 126:413-423. [PubMed]

Amir S, Brown ZW, Amit Z (1980) The role of acetaldehyde in the psychopharmacological effects of ethanol. In: Rigter H, Crabbe JC (eds) Alcohol tolerance and dependence. Elsevier/North Holland, Amsterdam, pp 317-337.

Amit Z, Brown ZW, Rockman G., Smith B, Amir S (1980) Acetaldehyde: A positive reinforcer mediating ethanol consumption. In: Begleiter H (ed) Biological effects of alcohol. Plenum Press, New York, pp 413-423.

Amit Z, Brown ZW, Amir S, Sutherland EA, Smith B (1980) Behavioral assessment of the role of acetaldehyde in mediation of alcohol intake in animals and humans. In: Eriksson K, Sinclair JD, Kiianmaa K (eds) Animal models in alcohol research. Academic Press, London, pp 159-165.

Amir S, Galina HZ, Amit Z (1979) Chronic naltrexone administration reverses the suppressive effect of crowding on body weight gain in rats. Neuropharmacology 18:905-907. [PubMed] [Abstract] [Content]

Amir S, Blair R, Shizgal P, Amit Z (1979) Dual mechanism mediating opiate effects? Science 205:424-425. [PubMed] [Abstract] [Content]

Amir S, Amit Z (1979) Enhanced analgesic effects of stress following chronic administration of naltrexone in rats. Eur J Pharmacol 59:137-140. [PubMed] [Abstract] [Content]

Amir S, Blair R, Amit Z (1979) Increased amphetamine potency following chronic naltrexone administration in rats. Life Sci 25:1407-1412. [PubMed] [Abstract] [Content]

Amir S, Solomon M, Amit Z (1979) The effect of acute and chronic naloxone administration on motor activation in the rat. Neuropharmacology 18:171-173. [PubMed] [Abstract] [Content]

Amir S, Amit Z (1979) The pituitary gland mediates acute and chronic pain responsiveness in stressed and non-stressed rats. Life Sci 24:439-448. [PubMed] [Abstract] [Content]

Amir S (1978) Brain aldehyde dehydrogenase: adaptive increase following prolonged ethanol administration in rats. Neuropharmacology 17:463-467 [PubMed] [Abstract]

Amir S, Amit Z (1978) Endogenous opioid ligands may mediate stress-induced changes in the affective properties of pain related behavior in rats. Life Sci 23:1143-1151. [PubMed] [Abstract] [Content]

Amir S, Stern MH (1978) Electrical stimulation and lesions of the medial forebrain bundle of the rat: changes in voluntary ethanol consumption and brain aldehyde dehydrogenase activity. Psychopharmacology (Berl) 57:167-174. [PubMed] [Content]

Amir S (1978) Brain and liver aldehyde dehydrogenase activity and voluntary ethanol consumption by rats: relations to strain, sex, and age. Psychopharmacology (Berl) 57:97-102. [PubMed] [Content]

Amir S (1977) Brain and liver aldehyde dehydrogenase: relations to ethanol consumption in Wistar rats. Neuropharmacology 16:781-784. [PubMed] [Abstract] [Content]

Amit Z, Corcoran ME, Amir S, Urca G (1973) Ventral hypothalamic lesions block the consumption of morphine in rats. Life Sci 13:805-816. [PubMed] [Abstract] [Content]


Lab Alumni

Barry Robinson, Resrach Techician and Lab administrator (1994-2014)
Kim Edelstein, MA, PhD (1992-1998)
Christian Beaulé, MA, PhD (1996-2002)
Jennifer Perrin, MA (2003-2005)
Elaine Waddington Lamont, PhD (2001-2005)
Lauren Segal, MA, PhD (2003-2010)
Suzanne Hood, PhD (2008-2010), Postdoctoral Fellow (2010-2011)
Luciana Gravotta, MA (2008-2010)
Michael Verwey, MA, PhD (2004-2011)
Valerie Harbour, MA, PhD (2005-2011)
Sherin Al-Safadi, PhD (2010-2014)
Doug Funk, Postdoctoral Fellow (1997-1999)
Andreas Arvanitogiannis, Postdoctoral Fellow (1997-1999)
Yuval Weigl, Postdoctoral Fellow (2007-2010)
Ruifeng Cao, Postdoctoral Fellow (2011-2016)
Ariana Frederick, MSc (2013-2016)

Marylin Rackover, BA (1992-1993)
Jane Barry-Shaw, BA (2001-2002)
Shannon McShane, BA (2001-2002)
Laura Renteria Diaz, BA (2002-2003)
Nicolina Ratto, BA (2002-2003)
Lawrence Koby, BA (2002-2003)
Natsumi Sawada, BA (2005-2006)
Zoe Hsu, BA (2005-2006)
Zehra Khoja, BA (2005-2006)
Amel Oudhini, BA (2005-2006)
Sara-Claude Michon, BA (2005-2006)
Germain Lam, BA (2008-2009)
Pamela Cassidy, BA (2008-2009)
Marie Coriaty, BA (2010-2011)
Kristyn Gullander, BA (2012-2013)
Ariana Frederick, BA (2012-2013)
Marie Branchaud, BA (2014-2015)
Spencer Rutherford, BA (2014-2015)
Tara Delorme, BA (2016-2017)



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