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Quantitative Physiological Imaging Lab

Some of our current projects are

  • Quantitative MRI of cerebrovascular and microstructural health in cardiovascular diseases,
  • Investigation of the effects of aerobic exercise and cognitive interventions on brain function and cognition in older adults,
  • Developing of quantitative susceptibility mapping methods to estimate oxygen extraction fraction in the venous vasculature and
  • Investigation of motor plasticity in the healthy brain using quantitative fMRI.
  1. Ashikuzzaman, M., Belasso, C., Golam Kibria, M., Bergdahl, A., Gauthier, C. J. & Rivaz, H. Low Rank and Sparse Decomposition of Ultrasound Color Flow Images for Suppressing Clutter in Real-Time. In press (2019).
  2. Huck, J., Wanner, Y., Fan, A. P., Jäger, A.-T., Grahl, S., Schneider, U., Villringer, A., Steele, C. J., Tardif, C. L., Bazin, P.-L. & Gauthier, C. J. High resolution atlas of the venous brain vasculature from 7 T quantitative susceptibility maps. Brain Struct Funct 224, 2467–2485 (2019). doi:10.1007/s00429-019-01919-4
  3. Intzandt, B., Sabra, D., Foster, C., Desjardins-Crépeau, L., Hoge, R. D., Steele, C. J., Bherer, L. & Gauthier, C. J. Higher cardiovascular fitness level is associated with lower cerebrovascular reactivity and perfusion in healthy older adults. Journal of Cerebral Blood Flow & Metabolism 0271678X19862873 (2019). doi:10.1177/0271678X19862873
  4. Badji, A., Sabra, D., Bherer, L., Cohen-Adad, J., Girouard, H. & Gauthier, C. J. Arterial stiffness and brain integrity: A review of MRI findings. Ageing Research Reviews 53, 100907 (2019). doi:10.1016/j.arr.2019.05.001
  5. Ashikuzzaman, M., Gauthier, C. J. & Rivaz, H. Global Ultrasound Elastography in Spatial and Temporal Domains. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 66, 876–887 (2019). doi:10.1109/TUFFC.2019.2903311
  6. Fan, A. P., Khalil, A. A., Fiebach, J. B., Zaharchuk, G., Villringer, A., Villringer, K. & Gauthier, C. J. Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke. Journal of Cerebral Blood Flow & Metabolism 0271678X19827944 (2019). doi:10.1177/0271678X19827944
  7. Gauthier, C. J. & Fan, A. P. BOLD signal physiology: Models and applications. NeuroImage 187, 116–127 (2019). doi:10.1016/j.neuroimage.2018.03.018
  8. Garrett, D. D., Lindenberger, U., Hoge, R. D. & Gauthier, C. J. Age differences in brain signal variability are robust to multiple vascular controls. Scientific Reports 7, 10149 (2017). doi:10.1038/s41598-017-09752-7
  9. Tardif, C. L., Steele, C. J., Lampe, L., Bazin, P.-L., Ragert, P., Villringer, A. & Gauthier, C. J. Investigation of the confounding effects of vasculature and metabolism on computational anatomy studies. NeuroImage 149, 233–243 (2017). doi:10.1016/j.neuroimage.2017.01.025
  10. Guidi, M., Huber, L., Lampe, L., Gauthier, C. J. & Möller, H. E. Lamina-dependent calibrated BOLD response in human primary motor cortex. NeuroImage 141, 250–261 (2016). doi:10.1016/j.neuroimage.2016.06.030
  11. Fan, A. P., Schäfer, A., Huber, L., Lampe, L., Smuda, S. von, Möller, H. E., Villringer, A. & Gauthier, C. J. Baseline oxygenation in the brain: Correlation between respiratory-calibration and susceptibility methods. NeuroImage 125, 920–931 (2016). doi:10.1016/j.neuroimage.2015.11.007
  12. Tardif, C. L.*, Gauthier, C. J.*, Steele, C. J., Bazin, P.-L., Schäfer, A., Schaefer, A., Turner, R. & Villringer, A. Advanced MRI techniques to improve our understanding of experience-induced neuroplasticity. NeuroImage 131, 55–72 (2016). doi:10.1016/j.neuroimage.2015.08.047 (* Shared first authorship)
  13. Dupuy, O., Gauthier, C. J., Fraser, S. A., Desjardins-Crèpeau, L., Desjardins, M., Mekary, S., Lesage, F., Hoge, R. D., Pouliot, P. & Bherer, L. Higher levels of cardiovascular fitness are associated with better executive function and prefrontal oxygenation in younger and older women. Front. Hum. Neurosci. 9, 66 (2015). doi:10.3389/fnhum.2015.00066
  14. Gorgolewski, K. J., Mendes, N., Wilfling, D., Wladimirow, E., Gauthier, C. J., Bonnen, T., Ruby, F. J. M., Trampel, R., Bazin, P.-L., Cozatl, R., Smallwood, J. & Margulies, D. S. A high resolution 7-Tesla resting-state fMRI test-retest dataset with cognitive and physiological measures. Scientific Data 2, 140054 (2015). doi:10.1038/sdata.2014.54
  15. Huber, L., Goense, J., Kennerley, A. J., Trampel, R., Guidi, M., Reimer, E., Ivanov, D., Neef, N., Gauthier, C. J., Turner, R. & Möller, H. E. Cortical lamina-dependent blood volume changes in human brain at 7T. NeuroImage 107, 23–33 (2015). doi:10.1016/j.neuroimage.2014.11.046
  16. Gauthier, C. J., Lefort, M., Mekary, S., Desjardins-Crépeau, L., Skimminge, A., Iversen, P., Madjar, C., Desjardins, M., Lesage, F., Garde, E., Frouin, F., Bherer, L. & Hoge, R. D. Hearts and minds: linking vascular rigidity and aerobic fitness with cognitive aging. Neurobiology of Aging 36, 304–314 (2015). doi:10.1016/j.neurobiolaging.2014.08.018
  17. Krieger, S. N., Gauthier, C. J., Ivanov, D., Huber, L., Roggenhofer, E., Sehm, B., Turner, R. & Egan, G. F. Regional reproducibility of calibrated BOLD functional MRI: Implications for the study of cognition and plasticity. NeuroImage 101, 8–20 (2014). doi:10.1016/j.neuroimage.2014.06.072
  18. Krieger, S. N., Ivanov, D., Huber, L., Roggenhofer, E., Sehm, B., Turner, R., Egan, G. F. & Gauthier, C. J. Using carbogen for calibrated fMRI at 7Tesla: Comparison of direct and modelled estimation of the M parameter. NeuroImage 84, 605–614 (2014). doi:10.1016/j.neuroimage.2013.09.035
  19. Gauthier, C. J., Madjar, C., Desjardins-Crépeau, L., Bellec, P., Bherer, L. & Hoge, R. D. Age dependence of hemodynamic response characteristics in human functional magnetic resonance imaging. Neurobiology of Aging 34, 1469–1485 (2013). doi:10.1016/j.neurobiolaging.2012.11.002
  20. Gauthier, C. J., Desjardins-Crépeau, L., Madjar, C., Bherer, L. & Hoge, R. D. Absolute quantification of resting oxygen metabolism and metabolic reactivity during functional activation using QUO2 MRI. NeuroImage 63, 1353–1363 (2012). doi:
  21. Tancredi, F. B., Gauthier, C. J., Madjar, C., Bolar, D. S., Fisher, J. A., Wang, D. J. J. & Hoge, R. D. Comparison of pulsed and pseudocontinuous arterial spin-labeling for measuring CO2-induced cerebrovascular reactivity. Journal of Magnetic Resonance Imaging 36, 312–321 (2012). doi:10.1002/jmri.23658
  22. Madjar, C., Gauthier, C. J., Bellec, P., Birn, R. M., Brooks, J. C. W. & Hoge, R. D. Task-related BOLD responses and resting-state functional connectivity during physiological clamping of end-tidal CO2. NeuroImage 61, 41–49 (2012). doi:10.1016/j.neuroimage.2012.02.080
  23. Gauthier, C. J. & Hoge, R. D. Magnetic resonance imaging of resting OEF and CMRO2 using a generalized calibration model for hypercapnia and hyperoxia. NeuroImage 60, 1212–1225 (2012). doi:10.1016/j.neuroimage.2011.12.056
  24. Gauthier, C. J. & Hoge, R. D. A generalized procedure for calibrated MRI incorporating hyperoxia and hypercapnia. Human Brain Mapping 34, 1053–1069 (2013). doi:10.1002/hbm.21495
  25. Gauthier, C. J., Madjar, C., Tancredi, F. B., Stefanovic, B. & Hoge, R. D. Elimination of visually evoked BOLD responses during carbogen inhalation: Implications for calibrated MRI. NeuroImage 54, 1001–1011 (2011). doi:10.1016/j.neuroimage.2010.09.059
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