PUBLICATIONS
List of selected publications
Copp, W., O’Flaherty, D.K., Wilds, C.J.* (2018) “Covalent capture of OGT’s active site using engineered human-E.coli chimera and intrastrand DNA cross-links”, Org. Biomol. Chem., 16, 9053 - 9058.
Sacre, L., O'Flaherty, D.K., Archambault, P., Copp, W., Peslherbe, G.H., Muchall, H.M., Wilds, C.J.* (2018) "O4-Alkylated-2’-deoxyuridine repair by O6-alkylguanine-DNA alkyltransferase is augmented by a C5-fluorine modification", ChemBioChem, 19, 575-582.
Liczner, C., Grenier, V., Wilds, C.J.* (2018) “Reversible Diselenide Cross-links are Formed Between Oligonucleotides Containing 2’-Deoxy-6-selenoinosine”, Tetrahedron Letters, 59, 38-41.
O’Flaherty, D.K., Wilds, C.J.* (2017) “AGT Activity Towards Intrastrand Cross-linked DNA is Modulated by the Alkylene Linker”, ChemBioChem, 18, 2351-2357.
Schoonhoven, N.M., O'Flaherty, D.K., McManus, F.P., Sacre, L., Noronha, A.M., Kornblatt, M.J.*, Wilds, C.J.* (2017) “Altering Residue 134 Confers an Increased Substrate Range of Alkylated
Nucleosides to the E. coli OGT Protein”, Molecules, 22, E1948.
Denisov, A., McManus, F.P., O’Flaherty, D.K., Noronha, A.M., Wilds, C.J.* (2017) “Structural Basis of Interstrand Cross-link Repair by O6-Alkylguanine DNA Alkyltransferase”, Org. Biomol. Chem., 15, 8361-8370.
Copp, W., Denisov, A., Xie, J., Noronha, A.M., Liczner, C., Safaee, N., Wilds, C.J.*, Gehring, K.* (2017) “Influence of Nucleotide Modifications at the C2’ Position on the Hoogsteen Base-Paired Parallel-Stranded Duplex of Poly(A) RNA”, Nucleic Acids Research, 45, 10321-10331.
Sacre, L., Wilds, C.J.* (2017) "Fluorine at the C5 Position of 2'-Deoxyuridine Enhances Repair of an O4-Methyl Adduct by O6-Alkylguanine DNA Alkyltransferases", European Journal of Organic Chemistry, 3003-3008.
O'Flaherty, D.K., Wilds, C.J.* (2017) "Site-specific Covalent Capture of Human O6-Alkylguanine-DNA- alkyltransferase using Single-stranded Intrastrand Cross-linked DNA", Org. Biomol. Chem., 15, 189-196.
Xu, W., Kool, D., O'Flaherty, D.K., Keating, A.M., Sacre, L., Egli, M., Noronha, A.M., Wilds, C.J., Zhao, L.* (2016) “O6-2'-Deoxyguanosine-butylene-O6-2'-deoxyguanosine DNA Interstrand Cross-Links are Replication-Blocking and Mutagenic DNA Lesions", Chemical Research in Toxicology, 29, 1872-1882.
O'Flaherty, D.K., Wilds, C.J.* (2016) " Preparation of Intrastrand {G}O6-Alkylene-O6{G} Cross-Linked Oligonucleotides", Curr. Protoc. Nucleic Acid Chem., 66, 5.17.1-5.17.24.
O'Flaherty, D.K., Patra, A., Su, Y., Guengerich, F.P., Egli, M.*,Wilds, C.J.* (2016) “Lesion Orientation of O4-Alkylthymidine Influences Replication by Human DNA Polymerase η", Chemical Science, 7, 4896-4904.
Abou Assi, H., Harkness, R., Martin-Pintado, N., Wilds, C.J., Campos-Olivas, R., Mittermaier, A., González, C.*, Damha, M.J.* (2016) "Stabilization of i-Motif Structures by 2′-β-Fluorination of DNA", Nucleic Acids Research, 44, 4998-5009.
Carter, A., Seaberg, M., Fan, H.-F., Sun, G., Wilds, C., Li, H.-W., Perkins, T.* (2016) “Sequence-Dependent Nanometer-Scale Conformational Dynamics of Individual RecBCD-DNA Complexes”, Nucleic Acids Research, 44, 5849-5860.
O'Flaherty, D.K., Wilds, C.J.* (2016) "O6-Alkylguanine DNA Alkyltransferase Repair Activity Towards Intrastrand Cross-Linked DNA is Influenced by the Internucleotide Linkage", Chemistry - An Asian Journal, 11, 576-583.
O'Flaherty, D.K., Guengerich, F.P., Egli, M.*, Wilds, C.J.* (2015) "Backbone Flexibility Influences Nucleotide Incorporation by Human Translesion DNA Polymerase η Opposite Intrastrand Cross-linked DNA", Biochemistry, 54, 7449-7456.
O'Flaherty, D.K., Wilds, C.J.* (2015) "Synthesis, Characterization and Repair of a Flexible O6-2’-Deoxyguanosine-alkylene-O6-2’-deoxyguanosine Intrastrand Cross-Link", Chemistry - A European Journal, 21, 10522-10529.
Ko, N.R., Cheong, J., Noronha, A.M., Wilds, C.J.*, Oh, J.K.* (2015) "Reductively-Sheddable Cationic Nanocarriers for Dual Chemotherapy and Gene Therapy with Enhanced Release", Colloids and Surfaces B: Biointerfaces, 126, 178-187.
McManus, F.P., Wilds, C.J.* (2014) "O6-Alkylguanine-DNA Alkyltransferase Mediated Repair of O4-Alkylated 2’-Deoxyuridines", ChemBioChem, 15, 1966-1977.
O'Flaherty, D.K., Denisov, A., Noronha, A.M., Wilds, C.J.* (2014) "NMR Structure of an Ethylene Interstrand Cross-Linked DNA which Mimics the Lesion Formed by 1,3-Bis(2-chloroethyl)-1-nitrosourea", ChemMedChem, 9, 2099-2103.
O'Flaherty, D.K., McManus, F.P., Noronha, A.M., Wilds, C.J.* (2014) "Synthesis of Building Blocks and Oligonucleotides Containing {T}O4-Alkylene-O4{T} Interstrand Cross-Links", Curr. Protoc. Nucleic Acid Chem., 5.13.1-5.13.19.
