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PUBLICATIONS

Publications

Rodrigues de Souza, F.; Guimaraes, A.P.; Cuya, R.; Puggina de Freitas, M.; Goncalvez, A.d.S.; Forgione, P.; Franca, T.C.C. Analysis of Coxiella burnetti dihydrofolate reductase via in silico docking with inhibitors and molecular dynamics simulationJ. Biomol. Struct. Dynam. 201734, ahead of print.


Ennis, D.; Despland, E.; Chen, F.; Forgione, P.; Bauce, E. Spruce Budworm Feeding and Oviposition are Stimulated by Monoterpenes in White Spruce Epicuticular WaxesInsect Sci. 201724, 73t.


Chacón-Huete, F.; Mangel, D.; Ali, M.; Sudano, A.; Forgione, P. High-Value Biomass-Derived 2,5-Furandicarboxylic Acid Derivatives via a Double Decarboxylative Cross-CouplingACS Sustainable Chemistry and Engineering 20175, 7071-7076. DOI


Bastos, L.C.; de Souza, F.R.; Guimaraes, A.P.; Sirouspour, M.; Guizado, T.R.C.; Forgione, P.; Ramalho, T.C.; Franca, T.C.C. Virtual screening, docking, and dynamics of potential new inhibitors of dihydrofolate reductase from Yersinia pestisJ. Biomol. Struct. Dynam. 201634, 73t.


Ortgies, D.; Hassanpour, A.; Chen, F.; Woo, S.; Forgione, P. Desulfination as an Emerging Strategy in Palladium-Catalyzed C-C Coupling ReactionsEuropean Journal of Organic Chemistry 20162016, 408-425. DOI


Mangel, D.; Buonomano, C.; Sevigny, S.; Di Censo, G.; Thevendran, G.; Forgione, P. Efficient desulfinative cross-coupling of heteroaromatic sulfinates with aryl triflates in environmentally friendly protic solventsHeterocycles (Invited paper in honour of Dr. Isao Kuwajima) 201590, 1228-1239. DOI


Chen, F.; Wong, N. W. Y.; Forgione, P. One-Pot Tandem Palladium-Catalyzed Decarboxylative Cross-Coupling and C-H Activation Route to ThienoisoquinolinesAdvanced Synthesis and Catalysis 2014356, 1725-1730. DOI


Hassanpour, A.; De Carufel, C.A.; Bourgault, S.; Forgione, P. Synthesis of 2,5-Diaryl-Substituted Thiphenes as Helical Mimetics: Towards the Modulation of Islet Amyloid Polypeptide (IAPP) Amyloid Fibril Formation and CytotoxicityChemistry A European Journal 201420, 2522-2528. DOI


Ortgies, D. H.; Forgione, P. A Ligand-Free Palladium Catalyzed Cross-Coupling of Aryl Sulfinates with Aryl BromidesSynlett 2013DOI

SynlettDO2013

Sévigny, S.; Forgione, P. Efficient Desulfinylative Cross-Coupling of Thiophene and Furan Sulfinates with Aryl Bromides in Aqueous MediaNew J. Chem. 201337, 589. DOI

NewJChemSS2013

Patents

Piekny, A.; Forgione, P., Thienoisoquinolines and their derivatives for the treatment of cancer, PCT Int. Appl. (2016), pp. 27701978


Stammers, T.; Barbeau, X.; Beaulieu, P.; Bertrand-Laperle, M.; Brochu, C.; Edwards, P.J.; Forgione, P.; Godbout, C.; Hucke, O.; Joly, M.-A. Landry, S.; Lepage, O.; Naud, J.; Pesant, M.; Poirier, M.; Poirier, M.; Thavonekham, B., Quinazolinone derivatives as viral polymerase inhibitors and their preparation and use in the treatment of hepatitis C viral infection, PCT Int. Appl. (2011), 203 pp. WO 2011032277 Link


Beaulieu, P.; Bonneau, P.; Coulombe, R.; Forgione, P.; Gillard, J.; Jakalian, A.; Rancourt, J., Viral polymerase inhibitors, PCT Int. Appl. (2010), 139 pp. WO 201037210 Link


Beaulieu, P.L.; Forgione, P.; Gagnon, A.; Godbout, C.; Joly, M.-A.; Llinas-Brunet, M.; Naud, J.; Poirier, M.; Rancourt, J., Preparation of 2-amido benzoic acid compounds as viral polymerase inhibitors, PCT Int. Appl. (2009), 236 pp. WO 2009076747 Link


Beaulieu, P.L.; Forgione, P.; Gagnon, A.; Godbout, C.; Naud, J.; Poirier, M.; Racourt, J.; Stammers, T.A.; Thavonekham, B., Preparation of substituted carbonylaminobenzoic acid for use as viral polymerase inhibitors, PCT Int. Appl. (2009), 170 pp. WO 2009018656 Link


Bailey, M.D.; Bilodeau, F.; Forgione, P.; Gorys, V.; Llinas-Brunet, M.; Naud, J.; O'Meara, J.; Poupart, M.-A., Preparation of peptides as inhibitors of hepatitis C virus NS3 protease, PCT Int. Appl. (2008), 94 pp. WO 2008098368 Link


Bailey, M. D.; Forgione, P.; Llinas-Brunet, M.; Poupart, M.-A., Hepatitis C Inhibitor Peptide Analogs, PCT Int. Appl. (2007), 64 pp. WO 2007009227 Link


Bailey, M. D.; Bhardwaj, P.; Forgione, P.; Ghiro, E.; Goudreau, N.; Halmos, T.; Llinas-Brunet, M.; Poupart, M.-A.; Rancourt, J., Preparation of Peptide Analogs as Hepatitis C Inhibitors, PCT Int. Appl. (2006), 162 pp. WO 2006000085 Link


Llinas-Brunet, M.; Bailey, M.; Bhardwaj, P.; Bilodeau, F.; Forgione, P.; Ghiro, E.; Goudreau, N.; Halmos, T.; Rancourt, J., Macrocyclic Peptides Active Against the Hepatitis C Virus, PCT Int. Appl. (2005), 119 pp. WO 2005070955 Link


Llinas-Brunet, M.; Bailey, M.; Bhardwaj, P.; Forgione, P.; Ghiro, E.; Goudreau, N.; Halmos, T.; Rancourt, J., Preparation of Macrocyclic Peptides Active Against the Hepatitis C Virus, PCT Int. Appl. (2005), 128 pp. WO 2005028501 Link


Bailey, M.; Bilodeau, F.; Forgione, P.; Poupart, M.-A., Hepatitis C Inhibitor Peptide Analogs, Pct Int. Provisional Appl. (2005), 78 pp. 13/140 PV (withdrawn, strategic decision)


Bailey, M.; Bhardwaj, P.; Bilodeau, F.; Cameron, D.; Forgione, P.; Halmos, T.; Naud, J.; Poupart, M.-A., Hepatitis C Inhibitor Peptide Analogs, Pct Int. Appl. (2005), 149 pp. 13/129 WO (withdrawn, strategic decision)


Llinas-Brunet, M.; Bailey, M. D.; Bhardwaj, P.; Bordeleau, J.; Forgione, P.; Ghiro, E.; Gorys, V.; Goudreau, N.; Goulet, S.; Halmos, T.; Rancourt, J., Preparation of Heterocyclic Peptides as Hepatitis C Inhibitors, PCT Int. Appl. (2004), 186 pp. WO 2004103996 Link

Presentations

Chacón-Huete, F.; Forgione, P., Biomass Furan Derivatived as Building Blocks in Organic Synthesis: Application of Decarboxylative Cross-Coupling Methodologies, 100th Canadian Chemistry Conference and Exhibition, Toronto, Canada, June 1, 2017.


Chen, F.; Forgione, P., Applications of Aromatic Sulfinates Derivatives in Synthesis - Using Pyridine as both Protecting Group and a Directing Group for Pd-Catalyzed ortho-halogenation, 100th Canadian Chemistry Conference and Exhibition, Toronto, Canada, May 31, 2017.


Tac, F.; Forgione, P., Palladium-Catalyzed Decarboxylative and Desulfinylative Cross-Coupling reactions of Diaryliodonium Salts, 100th Canadian Chemistry Conference and Exhibition, Toronto, Canada, May 31, 2017.


Forgione, P., Decarboxylative and Desulfinative Cross-coupling Reactions as a Versatile Synthetic Tool, 100th Canadian Chemistry Conference and Exhibition, Toronto, Canada, May 31, 2017.


Chen, F.; Forgione, P., Applications of Aromatic Sulfinates Derivatives in Synthesis - Using Pyridine as a Directing group for ortho-halogenation, Chemistry and Biochemistry Graduate Research Conference, Montreal, Canada, November 18, 2016.


Tac, F.; Forgione, P., Palladium-Catalyzed Decarboxylative and Desulfinylative Cross-Coupling reactions of Diaryliodonium Salts, Chemistry and Biochemistry Graduate Research Conference, Montreal, Canada, November 18, 2016.


Chacón-Huete, F.; Forgione, P., Double Decarboxylative Cross-Coupling Reactions on Biomass Derived FDCA, 99th Canadian Chemistry Conference and Exhibition, Halifax, Canada, June 5, 2016.


Forgione, P., Applications of Decarboxylative and Desulfinative Cross-Coupling Reactions, 7th Annual Meeting of the Centre for Green Chemistry and Catalysis, Montreal, Canada, 2016, 2016 (invited lecture).


Chen, F.; Forgione, P., One-pot Tandem Palladium-catalyzed Decarbozylative Cross-Coupling and C-H Activation: An Efficient Method to Access Thioisoquinoline Scaffolds, 26th Quebec and Ontario Mini-Symposium on Biological and Organic Chemistry, Montreal, Canada, November 6, 2015.


Forgione, P., Development and Applications of Decarboxylative and Desulfinylative Cross-Coupling Reactions, Ottawa-Carleton Chemistry Institute Seminar Series, Ottawa, Canada, 2015, 2015 (invited lecture).


Forgione, P., C-H Arylation in Combination with Decarboxylative Cross-Couplings as a Modular Route to Biologically Important Thiophene-Based Targets, The International Chemical Congress of Pacific Basin Societies (Pacifichem), Honolulu, Hawaii, United States of America, 2015, 2015 (invited lecture).


Forgione, P., Highly Regioselective Decarboxylative and Desulfinative Arylations for the Preparation of Heteroaromatics with Biological Applications, 98th Canadian Chemistry Conference and Exhibition, Ottawa, Canada, July, 2015 (invited lecture).


Forgione, P., Development and Applications of Decarboxylative and Desulfinylative Cross-Coupling Reactions, 97th Canadian Chemistry Conference and Exhibition, Vancouver, Canada, July, 2014 (invited lecture).


Forgione, P., Development and Applications of Decarboxylative and Desulfinylative Cross-Coupling Reactions, Paraza Pharma, Inc., Montreal, Quebec, Canada, July 11, 2013 (invited lecture).


Hassanpour, A.*; De Carufel, C. A.; Bourgault, S.; Forgione, P., Towards the Synthesis of Potential Inhibitors of Islet Amyloid Fibril Aggregates, Pharmaqam 5e Colloque Annuel, Montreal, Quebec, Canada, June 17, 2013.


Forgione, P., Concise and Modular Synthetic Routes to Thiophene Derived Inhibitors, 95th Canadian Chemistry Conference and Exhibition (CSC), Quebec City, Quebec, Canada, May 26-30, 2013 (invited lecture).


Sevigny, S.; Forgione, P., Heteroaromatic Sulfinates as Nucleophilic Coupling Partners in Palladium-Mediated Desulfinylative Cross-Couplings, 96th Canadian Chemistry Conference and Exhibition (CSC), Quebec City, Quebec, Canada, May 26-30, 2013.


Ortgies, D. H.; Forgione, P., Aryl-sulfinates: An Alternative to Organometallic Reagents in Palladium-Catalyzed Coupling Reactions, 96th Canadian Chemistry Conference and Exhibition (CSC), Quebec City, Quebec, Canada, May 26-30, 2013.


Chen, F.; Wong, N. W. Y.; Forgione, P., One-pot Tandem Catalyzed Decarboxylative Cross-coupling and C-H Activation Route to Thienoisoquinolines, 96th Canadian Chemistry Conference and Exhibition (CSC), Quebec City, Quebec, Canada, May 26-30, 2013.


Hassanpour, A.*; De Carufel, C. A.; Bourgault, S.; Forgione, P., Towards the Synthesis of Potential Inhibitors of Islet Amyloid Fibril Aggregates, 96th Canadian Chemistry Conference and Exhibition (CSC), Quebec City, Quebec, Canada, May 26-30, 2013.


Forgione, P., Concise and Modular Synthetic Routes to Thiophene Derived Inhibitors, 96th Canadian Chemistry Conference and Exhibition , Quebec, Canada, 2013, 2013.


Forgione, P., A Modular Synthesis of Potential (alpha)-Helix Mimics as Inhibitors of Islet Amyloid Fibrils, BIT's Drug Designology: Invited Speaker, Hainan, China, 2013, 2013.


Forgione, P., Decarboxylative and Desulfinative Cross-Coupling Reactions and Their Applications, Paraza Pharma Seminar Series: Invited Speaker, Montreal, Quebec, Canada, 2013, 2013.


Forgione, P., Development and Applications of Decarboxylative and Desulfinative Cross-Coupling Reactions, University of Guelph Departamental Seminar: Invited Speaker, Guelph, Canada, 2013, 2013.


Sevigny, S.; Forgione, P., Aryl sulfinates as Replacement of Organometallic Reagents in Palladium-Catalyzed Coupling Reactions, 15th Annual Chemistry and Biochemistry Graduate Research Conference (CBGRC), Montreal, Quebec, Canada, November 23, 2012.


Hassanpour, A.; Forgione, P., Synthesis and Evaluation of 2,5-Diaryl Substituted Thiophenes as Small Molecule alpha-Helix Mimetics, 15th Annual Chemistry and Biochemistry Graduate Research Conference (CBGRC), Montreal, Quebec, Canada, November 23, 2012.


Ortgies, D. H.; Barthelme, A.; Aly, S.; Desharnais, B.; Rioux, S.; Chen, F.; Forgione, P., Aryl-sulfinates: An Alternative to Organometallic Reagents in Palladium-Catalyzed Coupling Reactions, 4th Congress of the European Association for Chemical and Molecular Sciences, Prague, Czech Republic, August 27, 2012.


Forgione, P., Progress in the Palladium-Catalyzed Cross-Couplings Employing CO2 and SO2 Extrusions to form Biaryls, 95th Canadian Chemistry Conference and Exhibition (CSC), Calgary, Alberta, Canada, May 26-30, 2012 (invited lecture).


Wong, N. W. Y.; Forgione, P., Efficient Palladium Catalyzed Multi-Bond Forming Reactions for the Synthesis of Thienoisoquinolines, 4th Centre in Green Chemistry and Catalysis Annual Meeting, Montreal, Quebec, Canada, May 10, 2012.


Sevigny, S.; Forgione, P., Towards a Green Synthesis of Aryl-Substituted Heteroaromatics via a Palladium-Catalyzed Desulfinylative Cross-Coupling, 4th Centre in Green Chemistry and Catalysis Annual Meeting, Montreal, Quebec, Canada, May 10, 2012.


Forgione, P., Progress in the Palladium-Catalyzed Cross-Couplings Employing CO2 and SO2 Extrusions to Form Biaryls, 95th Canadian Chemistry Conference and Exhibition, Calgary, Alberta, Canada, 2012, 2012.


Forgione, P., Decarboxylative and Desulfinative Cross-Coupling Reactions and Their Applications, York University Seminar Series: Invited Speaker, Toronto, Canada, 2012, 2012.


Forgione, P., Decarboxylative and Desulfinative Cross-Coupling Reactions and Their Applications, Xerox Research Cebtre of Canada Seminar Series: Invited Speaker, Mississauga, Canada, 2012, 2012.


Forgione, P., Decarboxylative and Desulfinative Cross-Coupling Reactions and Their Applications, University of Toronto: Invited Speaker, Mississauga, Canada, 2012, 2012.


Forgione, P., Development and Applications of Decarboxylative and Desulfinative Cross-Coupling Reactions, Universite Laval, Chemistry Seminar Series: Invited Speaker, Quebec City, Quebec, Canada, 2012, 2012.


Forgione, P., Decarboxylative and Desulfinative Cross-Coupling Reactions and Their Applications, Delmar Chemicals Seminar Series: Invited Speaker, Montreal, Quebec, Canada, 2012, 2012.

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