Our research is focused on developing new methods for the formation of carbon-carbon bonds. This plays an important role in the synthesis of a wide-range of chemical structures, including many drugs that are used to treat numerous diseases. Towards this end, we employ carboxylic acids and their mimics to create novel reactive groups that improve on the current transition-metal based coupling partners. The employment of carboxylic acids has many advantages, including their wide availability, general stability and their low environmental impact since no metal based side-products are formed. While using sulfinate salts allow for a more facile extrusion of SO2 compared to CO2, rendering the coupling of aryl and heteroaromatic sulfinates with aryl bromides possible without the need of a co-catalyst.