Concordia University

http://www.concordia.ca/content/concordia/en/jmsb/faculty.html

Stylianos Perrakis, PhD

Professor, Finance
RBC Distinguished Professor in Financial Derivatives

Office: S-MB 12305 
John Molson Building,
1450 Guy
Phone: (514) 848-2424 ext. 2963
Email: stylianos.perrakis@concordia.ca

Stylianos Perrakis holds a Diploma in Mechanical-Electrical Engineering from the National Technical University in Athens, Greece, and an MSc and PhD from the University of California at Berkeley. He has also taught as a full professor at the University of Ottawa, and as a Visiting Professor at the University of Geneva, Switzerland, the University of California, Santa Barbara, the École Supérieure de Commerce of Reims, France, and the Athens Laboratory of Business Administration in Greece.

Dr. Perrakis has published widely in Economics, Finance and Management Science over the last 40 years. His articles have appeared in (among others) The American Economic Review, The Review of Economic Studies, The International Economic Review, Management Science, The Journal of Finance, The Journal of Business, The Review of Financial Studies, The Journal of Financial and Quantitative Analysis, The Journal of Futures Markets, The Journal of Banking and Finance, The Journal of Economic Dynamics and Control, The International Journal of Industrial Organization, and Economic Letters. He is also author of a monograph on Canadian Industrial Organization and co-author of a textbook on Investments that is currently in its 8th edition. He acts as a referee for over 20 journals, has served on the editorial board of Finance, the official publication of the French Finance Association, and is currently Associate Editor of Risk and Decision Analysis and Editor of the Multinational Finance Journal. His latest research interests are option pricing under transaction costs, microstructure in option markets and credit derivatives.

Dr. Perrakis has been the recipient of various distinctions throughout his career. Most recently, he was elected Fellow of the Royal Society of Canada in July 2007, became a member of Concordia University's Provost Circle of Distinction in July 2009 and was appointed RBC Professor of Financial Derivatives in June 2010. In 2013 he was elected member of the Board of Governors of the University of Macedonia, Thessaloniki, Greece.

Education

PhD (University of California, Berkeley)

Areas of Expertise

  • Differentiated industries
  • Economic regulation
  • Financial engineering
  • Option pricing
  • Portfolio selection


Research activities


Publications

Learning and memory, electrophysiology, neocortex, hippocampal formation, synapse

Overview: I use a variety of electrophysiological and pharmacological techniques to examine how short- and long-term alterations in the strength of synapses occur, and how these changes may contribute to learning and memory within cortical circuits.

A new memory requires the formation of a memory trace, or "engram", in the brain. First, the hippocampus and other nearby cortical areas are thought to integrate sensory inputs into a cohesive representation. Then, memory is stored more permanently through connections with other parts of the brain including the neocortex. A major mechanism through which circuits of the brain can learn is through long-lasting increases (or decreases) in the strength of synaptic connections between neurons. My lab examines how changes in synaptic strength occur in parahippocampal and neocortical regions of the rat. Electrophysiological recording techniques are used to monitor synaptic strength and to examine how neuromodulatory systems (cholingergic, dopaminergic) and rhythmic EEG activities control changes in how neurons interact with one another.

Both graduate and undergraduate students make important contributions to this research. Please contact me if you are interested in conducting an Honours thesis, Specialization project, or Science College project in the lab.

Funding

My research is funded by the Natural Sciences and Engineering Research Council (NSERC) Discovery Grant program.

Lab members

Iulia Glovaci, PhD candidate
Ariel Batallan-Burrowes, PhD candidate


Participation activities


Artistic performances

Batallán-Burrowes, A.A., and Chapman, C.A. (2018) Dopamine suppresses persistent firing in layer III lateral entorhinal cortex neurons. Neuroscience Letters; 674:70-74.

Lacroix, F., Villaruel, F.R., Sanio C., Sparks D.W., Chapman, C.A., Chaudhri, N. (2017) Optogenetic activation of the infralimbic cortex suppresses the return of appetitive Pavlovian-conditioned responding following extinction. Cerebral Cortex; Oct17:1-12.

Robinson, J.C., Chapman, C.A., Courtemanche, R. (2017) Gap junction modulation of low-frequency oscillations in the cerebellar granule cell layer. Cerebellum; 16:802-811.

Plourde, G., Reed, S.J., Chapman, C.A. (2016) Attenuation of high-frequency (50-200 Hz) thalamocortical electroencephalographic rhythms by isoflurane in rats is more pronounced for the thalamus than for the cortex. Anesthesia and Analgesia; 122:1818-1825.

Sparks, D., Chapman, C.A. (2016) Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum. Journal of Neurophysiology; 116:658-70.

Glovaci, I., Chapman, C.A. (2015) Activation of phosphatidylinositol-linked dopamine receptors induces a facilitation of glutamate-mediated synaptic transmission in the lateral entorhinal cortex. Public Library of Science One; 10:e0131948.

Frederick A, Bourget-Murray J, Chapman CA, Amir S, Courtemanche R (2014) Diurnal influences on electrophysiological oscillations and coupling in the dorsal striatum and cerebellar cortex of the anesthetized rat. Frontiers in Systems Neuroscience 8:145 [Abstract] [Content]

Sparks DW, Chapman CA (2014) Contribution of Ih to the relative facilitation of synaptic responses induced by carbachol in the entorhinal cortex during repetitive stimulation of the parasubiculum. Neuroscience 278C:81-92. [PubMed] [Content]

Glovaci I, Caruana DA, Chapman CA (2014) Dopaminergic enhancement of excitatory synaptic transmission in layer II entorhinal neurons is dependent on D(1)-like receptor-mediated signaling. Neuroscience 258:74-83. [PubMed] [Content]

Hutter JA, Chapman CA (2013) Exposure to cues associated with palatable food reward results in a dopamine D2 receptor-dependent suppression of evoked synaptic responses in the entorhinal cortex. Behav Brain Funct 9:37. [PubMed] [Content]

Barrett SG, Chapman CA (2013) Contribution of muscarinic M1 receptors to the cholinergic suppression of synaptic responses in layer II of the entorhinal cortex. Neurosci Lett 554:11-15. [PubMed] [Content]

Hutter JA, Martel A, Trigiani L, Barrett SG, Chapman CA (2013) Rewarding stimulation of the lateral hypothalamus induces a dopamine-dependent suppression of synaptic responses in the entorhinal cortex. Behav Brain Res 252:266-274. [PubMed] [Content]

Glasgow SD, Chapman CA (2013) Muscarinic depolarization of layer II neurons of the parasubiculum.PLoS One 8:e58901. [PubMed] [Content]

Horn KE, Glasgow SD, Gobert D, Bull SJ, Luk T, Girgis J, Tremblay ME, McEachern D, Bouchard JF, Haber M, Hamel E, Krimpenfort P, Murai KK, Berns A, Doucet G, Chapman CA, Ruthazer ES, Kennedy TE (2013) DCC expression by neurons regulates synaptic plasticity in the adult brain.Cell Rep 3:173-185. [PubMed] [Content]

Sparks DW, Chapman CA (2013) Cholinergic receptor activation induces a relative facilitation of synaptic responses in the entorhinal cortex during theta- and gamma-frequency stimulation of parasubicular inputs.Neuroscience 230:72-85. [PubMed] [Content]

Reed SJ, Plourde G, Tobin S, Chapman CA (2013) Partial antagonism of propofol anaesthesia by physostigmine in rats is associated with potentiation of fast (80-200 Hz) oscillations in the thalamus.Br J Anaesth 110:646-653. [PubMed] [Content]

Horn KE, Xu B, Gobert D, Hamam BN, Thompson KM, Wu CL, Bouchard JF, Uetani N, Racine RJ, Tremblay ML, Ruthazer ES, Chapman CA, Kennedy TE (2012) Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity. J Neurochem 122:147-161. [PubMed] [Content]

Glasgow SD, Glovaci I, Karpowicz LS, Chapman CA (2012) Cholinergic suppression of excitatory synaptic transmission in layers II/III of the parasubiculum. Neuroscience 201:1-11. [PubMed] [Content]

Pfaus JG, Tse TL, Werk CM, Chanda ML, Leblonde A, Harbour VL, Chapman CA (2009)Enhanced synaptic responses in the piriform cortex associated with sexual stimulation in the male rat. Neuroscience 164:1422-1430. [PubMed] [Content]

Glasgow SD, Chapman CA (2008)Conductances mediating intrinsic theta-frequency membrane potential oscillations in layer II parasubicular neurons.J Neurophysiol 100:2746-2756. [PubMed] [Content]

Chapman CA, Jones RS, Jung M (2008)Neuronal plasticity in the entorhinal cortex.Neural Plast 2008:314785. [PubMed] [Content]

Caruana DA, Chapman CA (2008)Dopaminergic suppression of synaptic transmission in the lateral entorhinal cortex. Neural Plast 2008:203514.[PubMed] [Content]

Kourrich S, Glasgow SD, Caruana DA, Chapman CA (2008)Postsynaptic signals mediating induction of long-term synaptic depression in the entorhinal cortex.Neural Plast 2008:840374. [PubMed] [Content]

Caruana DA, Nesbitt C, Mumby DG, Chapman CA (2008)Seizure activity in the rat hippocampus, perirhinal and prefrontal cortex associated with transient global cerebral ischemia.J Neural Transm 115:401-411. [PubMed] [Content]

Gosselin B, Sawan M, Chapman CA (2007)A low-power integrated bioamplifyer with a new active DC rejection scheme.IEEE Transactions on Biomedical Circuits and Systems 1:184-192. [Content]

Caruana DA, Reed SJ, Sliz DJ, Chapman CA (2007)Inhibiting dopamine reuptake blocks the induction of long-term potentiation and depression in the lateral entorhinal cortex of awake rats.Neurosci Lett 426:6-11. [PubMed] [Content]

Glasgow SD, Chapman CA (2007)Local generation of theta-frequency EEG activity in the parasubiculum.J Neurophysiol 97:3868-3879. [PubMed] [Content]

Hamam BN, Sinai M, Poirier G, Chapman CA (2007)Cholinergic suppression of excitatory synaptic responses in layer II of the medial entorhinal cortex.Hippocampus 17:103-113. [PubMed] [Content]

Caruana DA, Chapman CA (2006) Dopamine has bidirectional effects on synaptic responses to cortical inputs in layer II of the lateral entorhinal cortex.J Neurophysiol 96:3006-3015. [PubMed] [Content]

Werk CM, Klein H, Nesbitt C, Chapman CA (2006) Long-term depression in the sensorimotor cortex induced by repeated delivery of 10 Hz trains in vivo. Neurosicence 140:13-20. [PubMed] [Content]

Mueller D, Chapman CA, Stewart J (2006) Amphetamine induces dendritic growth in ventral tegmental area dopaminergic neurons in vivo via basic fibroblast growth factor. Neuroscience 137:727-735. [PubMed] [Content]

Werk C, Harbour VL, Chapman CA (2005) Induction of long-term potentiation leads to increased reliability of evoked neocortical spindles in vivo. Neuroscience 131:793-800. [PubMed] [Content]

Caruana DA, Chapman CA (2004) Stimulation of the parasubiculum modulates entorhinal cortex responses to piriform cortex inputs in vivo. J Neurophysiol 92:1226-1235. [PubMed] [Content]

Werk C, Chapman CA (2003) Long-term potentiation of polysynaptic responses in layer V of the sensorimotor cortex induced by theta-patterned tetanization in the awake rat. Cereb Cortex 13:500-507. [PubMed] [Content]

Kourrich S, Chapman CA (2003) NMDA receptor-dependent long-term synaptic depression in the entorhinal cortex in vitro. J Neurophysiol 89:2112-2119. [PubMed] [Content]

Bouras R, Chapman CA (2003) Long-term synaptic depression in the adult entorhinal cortex in vivo. Hippocampus 13:780-790. [PubMed] [Content]

Patenaude C, Chapman CA, Bertrand S, Congar P, Lacaille JC (2003) GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmission. J Physiol 553:155-167. [PubMed] [Content]

Froc DJ, Chapman CA, Trepel C, Racine RJ (2000) Long-term depression and depotentiation in sensorimotor cortex of the freely moving rat. J Neurosci 20:438-445. [PubMed] [Content]

Chapman CA, Lacaille JC (1999) Cholinergic induction of theta-frequency oscillations in hippocampal inhibitory interneurons and pacing of pyramidal cell firing. J Neurosci 19:8637-8645. [PubMed] [Content]

Chapman CA, Lacaille JC (1999) Intrinsic theta-frequency membrane potential oscillations in hippocampal CA1 interneurons of stratum lacunosum-moleculare. J Neurophysiol 81:1296-1307. [PubMed] [Content]

Pere Y, Chapman CA, Woodhall G, Robitaille R, Lacaille JC (1999) Differential induction of long-lasting potentiation of inhibitory postsynaptic potentials by theta patterned stimulation versus 100-Hz tetanization in hippocampal pyramidal cells in vitro. Neuroscience 90:747-757.Hippocampus 13:780-790. [PubMed] [Content]

St-Jacques R, Chapman A, Lacaille JC, Mohr G, Schipper HM (1999) Acceleration of ageing-related gliopathic changes and hippocampal dysfunction following intracerebroventricular infusion of cysteamine in adult rats. Neuroscience 90:1103-1113. [PubMed] [Content]

Chapman CA, Perez Y, Lacaille JC (1998) Effects of GABA(A) inhibition on the expression of long-term potentiation in CA1 pyramidal cells are dependent on tetanization parameters. Hippocampus 8:289-298. [PubMed] [Content]

Chapman CA, Trepel C, Ivanco TL, Froc DJ, Wilson K, and Racine RJ (1998) Changes in field potentials and membrane currents in rat sensorimotor cortex following repeated tetanization of the corpus callosum in vivo. Cereb Cortex 8:730-742. [PubMed] [Content]

Chapman CA, Xu Y, Haykin S, and Racine RJ (1998) Beta-frequency (15-35 Hz) electroencephalogram activities elicited by toluene and electrical stimulation in the behaving rat. Neuroscience 86:1307-1319. [PubMed] [Content]

Chapman CA, Racine RJ (1997) Converging inputs to the entorhinal cortex from the piriform cortex and medial septum: Facilitation and current source density analysis. J Neurophysiol 78:2602-2615. [PubMed] [Content]

Chapman A, Racine RJ (1997) Piriform cortex efferents to the entorhinal cortex in vivo: kindling-induced potentiation and the enhancement of long-term potentiation by low-frequency piriform cortex or medial septal stimulation. Hippocampus 7:257-270. [PubMed] [Content]

Allan LG, Siegel S, Kulatunga-Moruzi C, Eissenberg T, Chapman CA (1997) Isoluminance and contingent color aftereffects. Percept Psychophys 59:1327-1334. [PubMed] [Content]

Chapman CA, Yeomans JS, Blaha CD, Blackburn JR (1997) Increased striatal dopamine efflux follows scopolamine administered systemically or to the tegmental pedunculopontine nucleus. Neuroscience 76:177-186. [PubMed] [Content]

Haykin S, Racine RJ, Xu Y, Chapman CA (1996) Monitoring neuronal oscillations and signal transmission between cortical regions using time-frequency analysis of electroencephalographic activity. Proc IEEE 84:1295-1301. [Content]

Racine RJ, Chapman CA, Teskey GC, Milgram NW (1995) Post-activation potentiation in the neocortex. III. Kindling-induced potentiation in the chronic preparation. Brain Res 702:77-86. [PubMed] [Content]

Racine RJ, Chapman CA, Trepel CD, Teskey GC, Milgram NW (1995) Post-activation potentiation in the neocortex. IV. Multiple sessions required for induction of long-term potentiation in the chronic preparation. Brain Res 702:87-93. [PubMed] [Content]

Rashid K, Van der Zee CEEM, Ross GM, Chapman CA, Stanisz J, Riopelle RJ, Racine RJ, Fahnestock M (1995) An nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy. Proc Natl Acad Sci U S A 92:9495-9499. [PubMed] [Content]

Chapman CA, Becker S (1995) Model synapses with frequency potentiation characteristics can cooperatively enhance Hebbian learning. In: Bower JM (ed) The Neurobiology of Computation. Springer, pp 197-202.

Chapman CA, Yeomans JS (1994) Motor cortex and pyramidal tract axons responsible for electrically evoked forelimb flexion: refractory periods and conduction velocities. Neuroscience 59:699-711. [PubMed] [Abstract]

Yeomans JS, Hempel CME, Chapman CA (1993) Axons and synapses mediating startle-like responses evoked by electrical stimulation of the reticular formation in rats: symmetric and asymmetric collision effects. Brain Res 617:309-319. [PubMed] [Abstract]

Hempel CM, Zhou SS, Chapman CA, Yeomans JS (1993) Crossed reticular formation connections that mediate the startle reflex in rats. Brain Res 617:329-338. [PubMed] [Abstract]

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