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https://www.concordia.ca/content/concordia/en/research/aging/projects/Evaluating-a-combination-of-cognitive-behavioral-therapy-for-insomnia.html

Evaluating a combination of cognitive-behavioral therapy for insomnia with benzodiazepine withdrawal on cognitive function and sleep quality in the elderly

Evaluating a combination of cognitive-behavioral therapy for insomnia with benzodiazepine withdrawal on cognitive function and sleep quality in the elderly

A Pilot Study 

Benzodiazepines are prescribed abundantly in the elderly, mainly for complaints of anxiety and insomnia. While the recommended duration of treatment is usually only a few weeks, this is chronic in most cases. Numerous studies show the association between the chronic intake of benzodiazepines and the occurrence of comorbidities in the elderly, such as increased risk of falls, cognitive impairment, and dementia. Previous research has shown that the cessation of benzodiazepine therapy is accompanied by an improvement in cognitive performance, however residual effects remain and function is not returned to normal. This may be due to two major limitations of benzodiazepine withdrawal, firstly that approximately half of users will relapse to using benzodiazepines again, and that withdrawal measures alone do not address the underlying problem of chronic sleep disorders (e.g. insomnia) that are often the basis of benzodiazepine use, and have been shown to be independently associated with cognitive impairment. In this project, we propose to evaluate the effect of the current recommended treatment for insomnia, cognitive behavioural therapy (CBT-i), on cognition in elderly people withdrawing from prolonged consumption of benzodiazepines. We also aim to determine whether any improvement in cognitive performance is related to the improvement in sleep associated with treatment. 

Researchers
  • Thien Thanh Dang-Vu (CRIUGM) 
  • Nathan Cross (CRIUGM) 
  • Mehdi Essouni (CRIUGM) 
  • Ali Salimi (CRIUGM) 
  • Caroline Desrosiers (CRIUGM) 
  • Felix Guérin (CRIUGM) 
  • Lea Homer(CRIUGM) 
  • Cassandra Duguay (CRIUGM) 
  • Umberto Moretto (CRIUGM) 
  • Sophia Gregoire-Boyer (CRIUGM) 
  • Didier Paquin (CRIUGM)  
  • Julia Giraud (CRIUGM)
  • Elisabeth Houle (CRIUGM)
  • Melodee Mograss (CRIUGM) 
  • Oren Weiner (CRIUGM)
  • Soufiane Boucetta (CRIUGM)
  • Christian Berthomier (Physip SA)
  • Marie Brandewinder (Physip SA)  
  • Anik Guimond (CRIUGM)
  • Doris Clerc (CRIUGM) 
  • Francis Andriamampionona (CRIUGM)
  • David Lussier (CRIUGM)
  • Suzanne Gilbert (CRIUGM)
  • Sebastien Grenier (CRIUGM)
  • Jean-Phillippe (Concordia University)  
  • Cara Tannenbaum (CRIUGM)
Funding
  • CAREC (Comité Aviseur à la Recherche Clinique)
  • CRIUGM (Centre de recherche de l'Institut universitaire de gériatrie de Montréal)
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