Concordia University

http://www.concordia.ca/content/concordia/en/artsci/biology/faculty.html.html

Faculty

Vladimir Titorenko, PhD

Professor and Research Chair in Genomics, Cell Biology and Aging, Biology

Office: L-SP 501-13 
Richard J. Renaud Science Complex,
7141 Sherbrooke W.
Phone: (514) 848-2424 ext. 3424
Email: vladimir.titorenko@concordia.ca
Website(s): Titorenko Lab

Education

PhD (Moscow)

Research interests

Molecular and cellular mechanisms of aging and age-related disorders

Media

Our demonstration of a potent anti-tumor effect of lithocholic acid in cultured human cancer cells and our identification of the mechanisms underlying such effect of lithocholic acid has been highlighted in the news media, including: The Montreal Gazette; Radio-Canada; The Vancouver Sun; La Presse; Métro Montréal; The Regina Leader-Post; The Windsor Star; The Edmonton Journal; Calgari Herald; MSN Technologie; Bio-Medicine; Medical Xpress; Biology News Net; News Medical; Food Consumer; Science Daily; ScienceNewsline; Canada.com; Cancer; Anti-Aging News; Herbal Treatment; Le Devoir; FierceBiotech; Drug Discovery & Development; BrightSurf.com; Psychomedia; mediLexicon; Walfadjri; Medical News Today; Sante log; La Tribune; Bioscience Technology; Concordia NOW; The Concordian and others.

Dr. Vladimir Titorenko has been named “Personnalité de la semaine La Presse/Radio-Canada” (see here and here).

For a discussion of our research on a mechanism underlying a potent anti-tumor effect of lithocholic bile acid in cultured human cancer cells and its potential applications, please watch this YouTube video:


Teaching activities

BIOL 266 (Cell Biology)


Selected publications

Gafar, A.A., Draz, H.M., Goldberg, A.A., Bashandy, M.A., Bakry, S.,Khalifa, M.A., AbuShair, W., Titorenko,V.I. and Sanderson, J.T. Lithocholic acid induces endoplasmic reticulumstress, autophagy and mitochondrial dysfunction in human prostate cancer cells.PeerJ (2016) 4:e2445.

 

Kyryakov, P., Gomez-Perez, A., Glebov, A., Asbah, N., Bruno, L.,Meunier, C., Iouk, T. and Titorenko,V.I. Empirical verification of evolutionary theories of aging. Aging (2016) 8:2568-2589.

 

Arlia-Ciommo, A., Dakik, P., Leonov, A.,McAuley, M., Medkour, Y., Mohammad, K., Iouk, T., Simard, É. and Titorenko, V.I. Mechanisms throughwhich chemical compounds produced by mammals or plants delay chronologicalaging in yeast. Austin Biol. (2016)1:1011.


Dakik, P. and Titorenko, V.I. Communications between mitochondria, the nucleus,vacuoles, peroxisomes, the endoplasmic reticulum, the plasma membrane, lipiddroplets and the cytosol during yeast chronological aging. Front. Genet. (2016) 7:177.


Lutchman,V., Dakik, P., McAuley, M., Cortes, B., Ferraye, G., Gontmacher, L., Graziano,D., Moukhariq, F., Simard, É. and Titorenko,V.I. Six plant extracts delay yeast chronological aging through differentsignaling pathways. Oncotarget (2016)7:50845-50863.

 

Medkour,Y., Svistkova, V. and Titorenko, V.I. Cell-nonautonomousmechanisms underlying cellular and organismal aging. Int. Rev. Cell Mol. Biol. (2016) 321:259-297.

 

Arlia-Ciommo,A., Svistkova, V., Mohtashami, S. and Titorenko,V.I. A novel approach to the discovery of anti-tumor pharmaceuticals:searching for activators of liponecrosis. Oncotarget(2016) 7:5204-5225.

 

Klionsky,D.J. et al. (including Titorenko, V.I.).Guidelines for the use and interpretation of assays for monitoring autophagy (3rdedition). Autophagy (2016) 12:1-222.

 

Medkour,Y. and Titorenko, V.I. Mitochondriaoperate as signaling platforms in yeast aging. Aging (2016) 8:212-213.

 

Lutchman,V., Medkour, Y., Samson, E., Arlia-Ciommo, A., Dakik, P., Cortes, B., Feldman,R., Mohtashami, S., McAuley, M., Chancharoen, M., Rukundo, B., Simard, E. and Titorenko, V.I. Discovery of plantextracts that greatly delay yeast chronological aging and have differenteffects on longevity-defining cellular processes. Oncotarget (2016) 7:16542-16566.

 

Tremblay,M., Zhang, I., Bisht, K., Savage, J., Lecours, C., Parent, M., Titorenko, V.I. and Maysinger, D.Remodeling of lipid bodies by docosahexaenoic acid in activated microglialcells. J. Neuroinflammation (2016)13:116.

 

Piano,A. and Titorenko, V.I. The intricateinterplay between mechanisms underlying aging and cancer. Aging and Disease (2015) 6:56-75.

 

Beach,A., Leonov, A., Arlia-Ciommo, A., Svistkova, V., Lutchman, V. and Titorenko, V.I. Mechanisms  by which  different  functional states  of  mitochondria define  yeast  longevity. Int. J. Mol. Sci. (2015) 16:5528-5554.

 

Titorenko, V.I. andRachubinski, R.A. (editors). Origin and spatiotemporal dynamics of theperoxisomal endomembrane system. Frontiers Research Topic E-book. FrontiersMedia SA, Switzerland (2015).

 

Leonov,A., Arlia-Ciommo, A., Piano, A., Svistkova, V., Lutchman, V., Medkour, Y. and

Titorenko, V.I.Longevity extension by phytochemicals. Molecules(2015) 20:6544-6572.

 

Beach,A., Richard, V.R., Bourque, S., Boukh-Viner, T., Kyryakov, P., Gomez-Perez,A.,  Arlia- Ciommo, A., Feldman, R.,Leonov, A., Piano, A., Svistkova, V. and Titorenko,V.I. Lithocholic bile acid accumulated in yeast mitochondria orchestrates adevelopment  of an anti-aging cellularpattern by causing age-related changes in cellular proteome. Cell Cycle (2015) 14:1643-1656.

 

Shebani,S., Jones, N., Eid, R., Gharib, N., Arab, N., Titorenko, V.I., Vali, H., Young, P. and Greenwood, M. Inhibitionof stress mediated cell death by human Lactate Dehydrogenase B (LDHB) in yeast.FEMS Yeast Res. (2015) 15:fov032.

 

Sheibani,S., Richard, V.R., Beach, A., Leonov, A., Feldman, R., Khelghatybana, L.,  Piano, A., Greenwood, M., Vali, H. and Titorenko, V.I. Macromitophagy, neutrallipids  synthesis and peroxisomal fattyacid oxidation protect yeast from “liponecrosis”, a  previously unknown form of programmed celldeath. Cell Cycle (2014) 13:138-147.

 

Goldberg,A.A., Titorenko, V.I., Beach, A.,Abdelbaqi, K., Safe, S. and Sanderson, J.T. Ring- substituted analogs of 3, 3'-diindolylmethane (DIM) induceapoptosis and necrosis in androgen- dependent and -independent prostate cancercells. Invest. New Drugs (2014)32:25-36.

 

Burstein,M.T. and Titorenko, V.I. Amitochondrially targeted compound delays aging in yeast through a mechanismlinking mitochondrial membrane lipid metabolism to mitochondrial redox biology.Redox Biol. (2014) 2:305-307.

 

Richard,V.R., Bourque, S.D. and Titorenko, V.I.Metabolomic and lipidomic analyses of chronologically aging yeast. In: YeastGenetics. Methods and Protocols. Eds. Smith, J.S. and Burke, D.J. Humana Press,USA, pp. 359-373 (2014).

 

Arlia-Ciommo,A., Leonov, A., Piano, A., Svistkova, V. and Titorenko, V.I. Cell- autonomous mechanisms of chronological agingin the yeast Saccharomyces cerevisiae.Microbial Cell (2014) 1:164-178.

 

Martins,D., Titorenko, V.I. and English,A.M. Cells with impaired mitochondrial H2O2 sensinggenerate less •OH radicals and live longer. Antioxid.Redox. Signal. (2014) 21:1490-1503.

 

Richard,V.R., Bourque, S.D. and Titorenko, V.I.Metabolomic and lipidomic analyses of chronologically aging yeast. Methods Mol. Biol. (2014) 1205:359-373.

 

Arlia-Ciommo,A., Piano, A., Svistkova, V., Mohtashami, S. and Titorenko, V.I. Mechanisms underlying the anti-aging and anti-tumoreffects of lithocholic bile acid. Int.  J. Mol. Sci. (2014) 15:16522-16543.

 

Richard,V.R., Beach, A., Piano, A., Leonov, A., Feldman, R., Burstein, M.T.,Kyryakov,  P., Gomez-Perez, A.,Arlia-Ciommo, A., Baptista, S., Campbell, C., Goncharov, D.,  Pannu, S., Patrinos, D., Sadri, B.,Svistkova, V., Victor, A. and Titorenko,V.I.  Mechanism of liponecrosis, adistinct mode of programmed cell death. CellCycle (2014) 13:3707-3726.

 

Arlia-Ciommo,A., Piano, A., Leonov, A., Svistkova, V. and Titorenko, V.I. Quasi- programmed aging of budding yeast: atrade-off between programmed processes of cell proliferation, differentiation,stress response, survival and death defines yeast lifespan. Cell Cycle (2014) 13:3336-3349.

 

Titorenko, V.I. and Rachubinski,R.A. Origin and spatiotemporal dynamics of the peroxisomal endomembrane system.Front. Physiol. (2014) 5:493.

 

Filyak,Y., Finiuk, N., Mitina, N., Bilyk, O., Titorenko,V.I., Hrydzhuk, O., Zaichenko, A. and Stoika, R. A novel method for genetictransformation of yeast cells using oligoelectrolyte polymeric nanoscalecarriers. BioTechniques (2013) 54:35-43.

 

Beach,A., Burstein, M.T., Richard, V.R., Gomez-Perez, A., Leonov, A., Iouk, T. and Titorenko, V.I. A modular networkregulates longevity of chronologically aging yeast.  CellBiol. Res. Ther. (2013) 2:1000e110.

 

Richard,V.R., Leonov, A., Beach, A., Burstein, M.T., Koupaki, O., Gomez-Perez, A.,Levy, S., Pluska, L., Mattie, S., Rafeh, R., Iouk, T., Sheibani, S., Greenwood,M., Vali, H. and Titorenko, V.I.Macromitophagy is a longevity assurance process that in chronologically agingyeast limited in calorie supply sustains functional mitochondria and maintainscellular lipid homeostasis. Aging(2013) 5:234-269.

 

Beach,A. and Titorenko, V.I. EssentialRoles of Peroxisomally Produced and Metabolized Biomolecules in RegulatingYeast Longevity. In: Peroxisomes and their Key Role in Cellular Signaling andMetabolism. Ed. del Rio, L.A. Springer Science Business Media Dordrecht,Germany, pp. 153-167 (2013).

 

Titorenko, V.I. andHarkness, T.A.A. (editors). The spatiotemporal dynamics of longevity- definingcellular processes and its modulation by genetic, dietary and pharmacologicalanti-aging interventions. Frontiers Research Topic E-book. Frontiers Media SA,Switzerland (2013).

 

Leonov,A. and Titorenko, V.I. A network ofinterorganellar communications underlies cellular aging. IUBMB Life (2013) 65:665-674.

 

Beach,A. and Titorenko, V.I. Essentialroles of peroxisomally produced and metabolized biomolecules in regulatingyeast longevity. Subcell. Biochem.(2013)  69:153-167.

 

Beach,A., Richard, V.R., Leonov, A., Burstein, M.T., Bourque, S.D., Koupaki, O.,Juneau, M., Feldman, R., Iouk, T. and Titorenko,V.I. Mitochondrial membrane lipidome defines yeast longevity. Aging (2013) 5:551-574.

 

Goldberg,A.A., Beach, A., Titorenko, V.I. andSanderson, J.T. Bile acids induce apoptosis selectively in androgen-dependentand -independent prostate cancer cells.  PeerJ (2013) 1:e122.

 

Khatchadourian,A., Bourque, S.D., Richard, V.R., Titorenko,V.I. and Maysinger, D. Dynamics and regulation of lipid droplet formationin lipopolysaccharide (LPS)-stimulated microglia. Biochem. Biophys. Acta (2012) 1821:607-617.

 

Burstein,M.T., Beach, A., Richard, V.R., Koupaki, O., Gomez-Perez, A., Goldberg, A.A.,Kyryakov, P., Bourque, S.D., Glebov, A. and Titorenko, V.I. Interspecies chemical signals released into the environment may create xenohormetic,hormetic and  cytostatic selective forcesthat drive the ecosystemic evolution of longevity regulation  mechanisms. Dose-Response (2012) 10:75-82.

 

Kyryakov,P., Beach, A., Richard, V.R., Burstein, M.T., Leonov, A., Levy, S. and Titorenko, V.I. Caloric restrictionextends yeast chronological lifespan by altering a pattern of age-relatedchanges in trehalose concentration. Front.Physiol. (2012) 3:256.

 

Beach,A., Burstein, M.T., Richard, V.R., Leonov, A., Levy, S. and Titorenko, V.I. Integration ofperoxisomes into an endomembrane system that governs cellular aging.  Front.Physiol. (2012) 3:283.

 

Burstein,M.T., Kyryakov, P., Beach, A., Richard, V.R., Koupaki, O., Gomez-Perez, A.,Leonov, A., Levy, S., Noohi, F. and Titorenko,V.I. Lithocholic acid extends longevity of chronologically aging yeast onlyif added at certain critical periods of their lifespan. Cell Cycle (2012) 11:3443- 3462.

 

Titorenko, V.I. andHarkness, T.A.A. The spatiotemporal dynamics of longevity-defining cellularprocesses and its modulation by genetic, dietary and pharmacological anti-aginginterventions. Front. Physiol. (2012)3:419.

 

Titorenko, V.I. andTerlecky, S.R. Peroxisome metabolism and cellular aging. Traffic (2011) 12:252-259.

 

Beach,A. and Titorenko, V.I. In search ofhousekeeping pathways that regulate longevity. Cell Cycle (2011) 10:3042-3044.

 

Goldberg,A.A., Beach, A., Davies, G.F., Harkness, T.A.A., LeBlanc, A. and Titorenko, V.I. Lithocholic bile acidselectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget (2011) 2:761-782.

 

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