Concordia University

http://www.concordia.ca/content/concordia/en/artsci/biology/faculty.html.html

Faculty

Vladimir Titorenko, PhD

Professor and Research Chair in Genomics, Cell Biology and Aging, Biology

Office: L-SP 501-13 
Richard J. Renaud Science Complex,
7141 Sherbrooke W.
Phone: (514) 848-2424 ext. 3424
Email: vladimir.titorenko@concordia.ca
Website(s): Titorenko Lab

Education

PhD (Moscow)

Research interests

Molecular and cellular mechanisms of aging and age-related disorders

Media

Our demonstration of a potent anti-tumor effect of lithocholic acid in cultured human cancer cells and our identification of the mechanisms underlying such effect of lithocholic acid has been highlighted in the news media, including: The Montreal Gazette; Radio-Canada; The Vancouver Sun; La Presse; Métro Montréal; The Regina Leader-Post; The Windsor Star; The Edmonton Journal; Calgari Herald; MSN Technologie; Bio-Medicine; Medical Xpress; Biology News Net; News Medical; Food Consumer; Science Daily; ScienceNewsline; Canada.com; Cancer; Anti-Aging News; Herbal Treatment; Le Devoir; FierceBiotech; Drug Discovery & Development; BrightSurf.com; Psychomedia; mediLexicon; Walfadjri; Medical News Today; Sante log; La Tribune; Bioscience Technology; Concordia NOW; The Concordian and others.

Dr. Vladimir Titorenko has been named “Personnalité de la semaine La Presse/Radio-Canada” (see here and here).

For a discussion of our research on a mechanism underlying a potent anti-tumor effect of lithocholic bile acid in cultured human cancer cells and its potential applications, please watch this YouTube video:


Teaching activities

BIOL 266 (Cell Biology)


Selected publications

Medkour,Y., Svistkova, V. and Titorenko, V.I. Cell-non-autonomous mechanisms underlyingcellular and organismal aging. Int. Rev. Cell Mol. Biol. (2015) in press.  

 

Shebani,S., Jones, N., Eid, R., Gharib, N., Arab, N., Titorenko, V.I., Vali, H., Young,P. and Greenwood, M. Inhibition of stress mediated cell death by human LactateDehydrogenase B (LDHB) in yeast. FEMS Yeast Res. (2015) 15:fov032.

 

Beach,A., Richard, V.R., Bourque, S., Boukh-Viner, T., Kyryakov, P., Gomez-Perez, A.,Arlia-Ciommo, A., Feldman, R., Leonov, A., Piano, A., Svistkova, V. andTitorenko, V.I. Lithocholic bile acid accumulated in yeast mitochondriaorchestrates a development of an anti-aging cellular pattern by causingage-related changes in cellular proteome. Cell Cycle (2015) 14:1643-1656.

 

Leonov,A., Arlia-Ciommo, A., Piano, A., Svistkova, V., Lutchman, V., Medkour, Y. andTitorenko, V.I. Longevity extension by phytochemicals. Molecules (2015)20:6544-6572.


Beach, A., Leonov, A.,Arlia-Ciommo, A., Svistkova, V., Lutchman, V. and Titorenko, V.I. Mechanisms by which different functional states of mitochondriadefine yeast longevity. Int. J. Mol. Sci. (2015) 16:5528-5554.


Piano, A. and Titorenko, V.I. The intricate interplay between mechanisms underlying aging and cancer. Aging and Disease (2015) 6:56-75.

 

Titorenko, V.I. and Rachubinski, R.A. (editors). Origin and spatiotemporal dynamics of the peroxisomal endomembrane system. Frontiers Research Topic E-book. Frontiers Media SA, Switzerland (2015).

 

Sheibani, S., Richard, V.R., Beach, A., Leonov, A., Feldman, R.,Khelghatybana, L., Piano, A., Greenwood, M., Vali, H. and Titorenko, V.I. Macromitophagy, neutral lipids synthesis and peroxisomal fatty acid oxidation protect yeast from “liponecrosis”, a previously unknown form of programmed cell death. Cell Cycle (2014) 13:138-147.

 

Goldberg, A.A., Titorenko, V.I., Beach, A., Abdelbaqi, K., Safe, S. and Sanderson, J.T. Ring-substituted analogs of 3,3'-diindolylmethane (DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells. Invest. New Drugs (2014) 32:25-36.

 

Burstein, M.T. and Titorenko, V.I. A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology. Redox Biol. (2014) 2:305-307.

 

Arlia-Ciommo, A., Leonov, A., Piano, A., Svistkova, V. and Titorenko,V.I. Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae. Microbial Cell (2014) 1:164-178.

 

Martins, D., Titorenko, V.I. and English, A.M. Cells with impaired mitochondrial H2O2 sensing generate less •OH radicals and live longer. Antioxid. Redox. Signal. (2014) 21:1490-1503.

 

Richard, V.R., Bourque, S.D. and Titorenko, V.I. Metabolomic and lipidomic analyses of chronologically aging yeast. Methods Mol. Biol. (2014)1205:359-373.

 

Arlia-Ciommo, A., Piano, A., Svistkova, V., Mohtashami, S. and Titorenko, V.I. Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid. Int. J. Mol. Sci. (2014) 15:16522-16543.

 

Richard, V.R., Beach, A., Piano, A., Leonov, A., Feldman, R., Burstein,M.T., Kyryakov, P., Gomez-Perez, A., Arlia-Ciommo, A., Baptista, S., Campbell,C., Goncharov, D., Pannu, S., Patrinos, D., Sadri, B., Svistkova, V., Victor,A. and Titorenko, V.I. Mechanism of liponecrosis, a distinct mode of programmed cell death. Cell Cycle (2014) 13:3707-3726.

 

Arlia-Ciommo, A., Piano, A., Leonov, A., Svistkova, V. and Titorenko,V.I. Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan. Cell Cycle (2014) 13:3336-3349.

 

Titorenko, V.I. and Rachubinski, R.A. Origin and spatiotemporal dynamics of the peroxisomal endomembrane system. Front. Physiol. (2014) 5:493.

 

Richard, V.R., Bourque, S.D. and Titorenko, V.I. Metabolomic and lipidomic analyses of chronologically aging yeast. In: Yeast Genetics. Methods and Protocols. Eds. Smith, J.S. and Burke, D.J. Humana Press, USA, pp. 359-373(2014).

 

Titorenko, V.I. and Harkness, T.A.A. (editors). The spatiotemporal dynamics of longevity-defining cellular processes and its modulation by genetic, dietary and pharmacological anti-aging interventions. Frontiers Research Topic E-book. Frontiers Media SA, Switzerland (2013).

 

Filyak, Y., Finiuk, N., Mitina, N., Bilyk, O., Titorenko, V.I.,Hrydzhuk, O., Zaichenko, A. and Stoika, R. A novel method for genetic transformation of yeast cells using oligoelectrolyte polymeric nanoscale carriers. BioTechniques (2013) 54:35-43.

 

Beach, A., Burstein, M.T., Richard, V.R., Gomez-Perez, A., Leonov, A.,Iouk, T. and Titorenko, V.I. A modular network regulates longevity of chronologically aging yeast. Cell Biol. Res. Ther. (2013) 2:1000e110.

 

Richard, V.R., Leonov, A., Beach, A., Burstein, M.T., Koupaki, O.,Gomez-Perez, A., Levy, S., Pluska, L., Mattie, S., Rafeh, R., Iouk, T.,Sheibani, S., Greenwood, M., Vali, H. and Titorenko, V.I. Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis. Aging (2013) 5:234-269.

 

Leonov, A. and Titorenko, V.I. A network of interorganellar communications underlies cellular aging. IUBMB Life (2013) 65:665-674.

 

Beach, A. and Titorenko, V.I. Essential roles of peroxisomally produced and metabolized biomolecules in regulating yeast longevity. Subcell. Biochem.(2013) 69:153-167.

 

Beach, A., Richard, V.R., Leonov, A., Burstein, M.T., Bourque, S.D.,Koupaki, O., Juneau, M., Feldman, R., Iouk, T. and Titorenko, V.I. Mitochondrial membrane lipidome defines yeast longevity. Aging (2013)5:551-574.

 

Goldberg, A.A., Beach, A., Titorenko, V.I. and Sanderson, J.T. Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells. PeerJ (2013) 1:e122.

 

Beach, A. and Titorenko, V.I. Essential Roles of Peroxisomally Produced and Metabolized Biomolecules in Regulating Yeast Longevity. In: Peroxisomes and their Key Role in Cellular Signaling and Metabolism. Ed. del Rio, L.A. Springer Science Business Media Dordrecht, Germany, pp. 153-167 (2013).

 

Khatchadourian, A., Bourque, S.D., Richard, V.R., Titorenko, V.I. and Maysinger, D. Dynamics and regulation of lipid droplet formation inlipopolysaccharide (LPS)-stimulated microglia. Biochem. Biophys. Acta (2012)1821:607-617.

 

Burstein, M.T., Beach, A., Richard, V.R., Koupaki, O., Gomez-Perez, A.,Goldberg, A.A., Kyryakov, P., Bourque, S.D., Glebov, A. and Titorenko, V.I. Interspecies chemical signals released into the environment may create xenohormetic, hormetic and cytostatic selective forces that drive the ecosystemic evolution of longevity regulation mechanisms. Dose-Response (2012)10:75-82.

 

Kyryakov, P., Beach, A., Richard, V.R., Burstein, M.T., Leonov, A.,Levy, S. and Titorenko, V.I. Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration.Front. Physiol. (2012) 3:256.

 

Beach, A., Burstein, M.T., Richard, V.R., Leonov, A., Levy, S. and Titorenko, V.I.  Integration of peroxisomes into an endomembrane system that governs cellular aging. Front.Physiol. (2012) 3:283.

 

Burstein, M.T., Kyryakov, P., Beach, A., Richard, V.R., Koupaki, O.,Gomez-Perez, A., Leonov, A., Levy, S., Noohi, F. and Titorenko, V.I. Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan. Cell Cycle (2012) 11:3443-3462.

 

Titorenko, V.I. and Harkness, T.A.A. The spatiotemporal dynamics of longevity-defining cellular processes and its modulation by genetic, dietary and pharmacological anti-aging interventions. Front. Physiol. (2012) 3:419.

 

Titorenko, V.I. and Terlecky, S.R. Peroxisome metabolism and cellular aging. Traffic (2011) 12:252-259.

 

Beach, A. and Titorenko, V.I. In search of housekeeping pathways that regulate longevity. Cell Cycle (2011) 10:3042-3044.

 

Goldberg, A.A., Beach, A., Davies, G.F., Harkness, T.A.A., LeBlanc, A.and Titorenko, V.I. Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget (2011) 2:761-782.

 

Goldberg, A.A., Richard, V.R., Kyryakov, P., Bourque, S.D., Beach, A.,Burstein, M.T., Glebov, A., Koupaki, O., Boukh-Viner, T., Gregg, C., Juneau,M., English, A.M., Thomas, D.Y. and Titorenko, V.I. Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. Aging (2010) 2:393-414.

 

Goldberg, A.A., Kyryakov, P., Bourque, S.D. and Titorenko, V.I.Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level. Aging (2010) 2:361-370.

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