One of these groups of molecules is the most potent longevity-extending pharmacological intervention yet described in scientific literature: a specific extract of willow bark.
Willow bark was commonly used during the time of Hippocrates, when people were advised to chew on it to relieve pain and fever. The study showed that it increases the average and maximum chronological lifespan of yeast by 475 per cent and 369 per cent, respectively. This represents a much greater effect than rapamycin and metformin, the two best drugs known for their anti-ageing effects.
“These six extracts have been recognized as non-toxic by Health Canada, and already exhibit recognized health benefits in humans,” says Simard.
“But first, more research must be done. That’s why Idunn Technologies is collaborating with four other universities for six research programs, to go beyond yeast, and work with an animal model of ageing, as well as two cancer models.”
Partners in research: This study was supported in part by grants from the Natural Sciences and Engineering Research Council of Canada, the Fonds de recherche du Québec – Nature et technologies, the Concordia University Graduate Fellowship Award, the Concordia University Chair Fund and the Concordia University Undergraduate Research Award.
The co-authors of this study are Vicky Lutchman, Younes Medkour, Eugenie Samson, Anthony Arlia-Ciommo, Pamela Dakik, Berly Cortes, Rachel Feldman, Sadaf Mohtashami, Mélissa McAuley, Marisa Chancharoen, Belise Rukundo and Vladimir I. Titorenko (Concordia); Éric Simard (Idunn Technologies).
Read the cited study, Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes, led by Vladimir Titorenko, a professor in the Department of Biology at Concordia.