Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of a phenotype including dysfunctional adipose tissue expansion and ectopic triglyceride storage closely related to clustering cardiometabolic risk factors. Physiological characteristics of abdominal adipose tissues such as adipocyte size and number, lipolytic responsiveness, lipid storage capacity, and inflammatory cytokine production are significant correlates and even possible determinants of the increased cardiometabolic risk associated with visceral obesity. The seminar will address the critical role of the adipocyte and its morphology in the association between abdominal obesity and cardiometabolic risk factors and describe some of the cellular, molecular and metabolic alterations characterizing visceral adipose tissue in individuals with abdominal obesity.
At the end of the presentation participants will:
Appreciate the critical role of the adipocyte and its morphology in the association between abdominal obesity and cardiometabolic risk factors;
Better understand the cellular, molecular and metabolic alterations characterizing visceral adipose tissue in individuals with abdominal obesity.
Dr. Andre Tchernof is Professor at Laval University School of Nutrition since 2000. After a Bachelor's degree in Biochemistry (1991), a Master’s degree (1992) and a Doctoral degree (1996) in Physiology-Endocrinology at Laval University, he underwent two postdoctoral trainings in Molecular Endocrinology (Laval University Medical Center, 1996-97) and in Endocrinology & Metabolism at the University of Vermont (1997-2000). He then obtained salary awards from the Fonds de la recherche en santé du Québec and Canadian Institutes of Health Research (2000-2012).
His research projects have been funded among others by the Canadian Institutes of Health Research, the Canadian Diabetes Association and the National Science and Engineering Research Council. He also co-directed the Research Chair in Bariatric and Metabolic Surgery and is co-director of the Institutionally-approved Obesity Tissue Bank at Institut Universitaire de Cardiologie et Pneumologie de Québec.
He contributed to more than 130 publications in peer-reviewed journals. His research interests relate to the metabolic complications of obesity and body fat distribution, with a particular emphasis on adipose tissue physiology. Experimental approaches combine cellular biology techniques with biochemistry, genomics, transcriptomics and clinical investigation in humans.
Published work has involved collaborations with many surgeons from various surgery services at Laval University-affiliated hospitals, including studies on the impact of bariatric surgery. His reserach allows clinical observations to be linked with the cellular characteristics or mechanisms underlying pathophysiological conditions such as abdominal obesity and related cardiometabolic complications.