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BIOPHYSICAL STRUCTURE-FUNCTION RELATIONSHIPS

We study of how non-covalent, molecular interactions (lipid-lipid, lipid-protein) govern the interfacial structure, organization and fluidity/elasticity of biological membranes and how these properties control membrane function. These inter-relationships are governed by a complex set of physicochemical properties.

We use model membranes such as lipid monolayers and liposomes to probe the interactions at membrane surfaces.  Ongoing projects include i) the study of sequence-structure function relationships in membrane disrupting peptides that have potential as antimicrobials and anticancer agents; ii) the impact of airborne pollutants (small molecule oxidants and nanoparticulate) on the functional properties of lung surfactant and iii) nanoparticle and aerosol drug delivery to the lungs.

 

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