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Functional and structural architecture of the cerebellum

Reference number: 11007
Supervisor: Christopher J. Steele

Program description

The Neural Architecture, Behaviour, and Connectivity lab seeks an outstanding postdoctoral fellow to join us in our quest to understand the functional and structural architecture of the cerebellum. The project focuses on investigating both cerebellar functional connectivity (including its cortex, nuclei, cerebral cortex/subcortex in human fMRI) and on developing ground-truth models of white matter connectivity with serial optical coherence microscopy in non-human animals. On the functional side, we will identify potential links between functional connectivity and individual differences in motor and/or cognitive behaviour that may be useful biomarkers for aging-related changes in motor performance. On the structural side, we will develop the first systems-level model of cerebellar structural connectivity at micron resolution that will enhance our understanding of brain function and facilitate the development of connectivity-based models of disease (e.g., Alzheimer’s propagation; stroke disconnection). As a part of our team, you will explore these fundamental questions and help develop a next-generation platform for microscopic assessment of anatomical connectivity. The candidate is expected to contribute their microscopy experience and also to take a leadership role within the lab, working closely with multi-disciplinary collaborators and graduate students, co-supervising students with related fields of interest, writing manuscripts, and preparing and carrying out experiments.

Academic qualifications required

PhD in Psychology/Neuroscience, Biomedical Engineering or related field with experience in imaging and image analysis.

The candidate will have a strong interest in the cerebellum and significant expertise in optical coherence microscopy and the assessment of structural connectivity (or commensurate experience with similar microscopic approaches).

Complementary experience with related microscopy techniques and reconstructions will also be considered a strong asset (e.g., polarized light imaging, structure-tensor reconstruction).

Experience with structural covariance and/or functional connectivity is an asset.

Timeline

Horizon position is expected to be filled as soon as possible but no later than March 1, 2024.

Submission process

Application checklist

  • One to three (1-3) page research statement demonstrating fit with the program described above
  • Current curriculum vitae demonstrating research excellence and a capacity for leadership in the domain (maximum 5 pages)
  • Two letters of reference from academic supervisors or current employers to be sent via e-mail directly to Christopher Steele AND Neuralabc lab
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