Canada's first training program for Synthetic Biology
Supported by the NSERC-CREATE program
My research focuses on introducing modularity to the nuclease deficient CRISPR/dCas9 system by controlling its half-life in yeast. I will also combine the system with transcriptional activating domains to study oscillating effects.
My research focuses on the humanization of yeast for bio-therapeutic applications. I am constructing a library of yeast with the ability to produce exosomes containing human gene products that can be internalized by target human cell populations. These nanoparticles have exciting potential applications as vehicles for gene therapy, therapeutic RNAs and novel biologics.
My project consists in developing a high-throughput platform for single cell screening using microfluidics and optics. It will allow us to culture clonal cell lines and isolate individual cells with desired traits using optical tweezers.
My research is focused on the computational design of RNA-based circuits for selective targeting and silencing of pathogenic genes.
My research focuses on hybridizing synthetic biology and microfluidics to create a novel, low-cost in-vitro diagnostic for infectious disease detection. I am working on building a protein-based biosensor for rapid analyte detection at the point-of-care.
My project is designing an automated gut-on-a-chip device that would allow the testing of several conditions in parallel. I will use the device to test different types and concentrations of chemotherapeutic agents, as well as different bacteria strains found in the gut microbiota.
My research focus is on identifying and creating tools for glycan engineering. These tools will be used to humanize the glycome of yeast exosomes to develop a novel system for delivering a payload into human cells.
I am trying to develop a model for an oscillating gene circuit that will then be tested in a wet lab. The goal is for the circuit to have a short period of around 10-20 minutes.
My research aim is to create and characterize a yeast model organism with a fully humanized sterol biosynthesis pathway. This model organism will be useful to study Mendelian diseases involving genes implicated in this essential metabolic pathway.
I am using microfluidic technologies to improve culture media for clean meat production.
My research focuses on investigating the trade-off between metabolic burden and precision of synthetic circuits in E. coli. I use a microfluidic platform called the mother machine to observe single-cell dynamics in a tightly controlled environment.
My research aims to develop novel sugar binding proteins for use in cancer diagnostics and therapeutics. We are using high-throughput directed evolution in combination with computational methods to excel the production of these binding proteins.
My research project focuses on the fundamental aspects of engineering to improve GPCR signaling in yeast as a platform/tool for the study of heterologous GPCR and for potential for drug discovery.
Orly Weinberg
SynBioApps@concordia.ca
(514) 848-2424 ext. 2798
7141 Sherbrooke Street West
GE-120.03
Montreal, QC H4B 1R6
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