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SynBioApps

Canada's first training program for Synthetic Biology

Supported by the NSERC-CREATE program

Alaa Selim

Alaa Selim 

MSc, Dr. Shih's lab

In my research, I use digital microfluidics (DMF) as a platform to expand the abilities of Biosensors, developing a protein-based biosensor that will automate the process of analyte detection.

Alaa Selim

Brandon Jaunky

Brandon Jaunky

MSc, Dr. Kharma's lab

My research focuses on introducing modularity to the nuclease deficient CRISPR/dCas9 system by controlling its half-life in yeast. I will also combine the system with transcriptional activating domains to study oscillating effects.

Brandon Jaunky

Charlotte Golden

Charlotte Golden 

MSc, Dr. Brett's lab

My research focuses on the isolation and humanization of yeast exosomes for use as bio-therapeutics. I am constructing a library of yeast with proteins, lipids, and sugars that release bioactive exosome populations that can be recognized and internalized by human cell targets.

Charlotte Golden

Chiara Leal Alves

Chiara Leal Alves

PhD, Dr. Shih's lab

My research involves genetic engineering of cellulase enzymes to create enzymes capable of degrading cellulosic materials for biofuels production. I am doing directed evolution studies using microfluidics devices under ionic conditions.

Chiara Leal Alves

Curtis Logan

Curtis Logan

MSc, Dr. Brett’s lab

My research focuses on the humanization of yeast for bio-therapeutic applications. I am constructing a library of yeast with the ability to produce exosomes containing human gene products that can be internalized by target human cell populations. These nanoparticles have exciting potential applications as vehicles for gene therapy, therapeutic RNAs and novel biologics.

Curtis Logan

Devina Singh

Devina Singh

MSc, Dr. Kachroo's lab

In humans, disruption of highly conserved essential cellular machinery has been linked to diverse diseases. I am focusing on these conserved human genes and propose to systematically “humanize” yeast cells by replacing each essential yeast gene with the human version. 

Devina Singh

Farhat Zafar

Farhat Zafar

MSc, Dr. Kachroo's lab

Human disease can be studied through the “humanization” of yeast cells. My research focuses on replacing a gene in the sterol biosynthesis pathway of Saccharomyces cerevisiae with its human ortholog in order to study mevalonate kinase deficiency.

Farhat Zafar

Felipe Perez

Felipe Perez

MASc, Dr. Shih’s and Dr. Potvin-Trottier’s labs

My project consists in developing a high-throughput platform for single cell screening using microfluidics and optics. It will allow us to culture clonal cell lines and isolate individual cells with desired traits using optical tweezers.

Felipe Perez

F. Ifthiha Mohideen

F. Ifthiha Mohideen

PhD, Dr. Kwan's lab

Using synthetic biology tools, I am engineering an improved biocatalyst for the production of a high value anthracycline anticancer drug. Using a novel in vitro enzymatic pathway, I have produced modified sugar-donor substrates for the enzymatic synthesis of anthracyclines.

F. Ifthiha Mohideen

Giselle McCallum

Giselle McCallum

PhD, Dr. Potvin-Trottier's lab

My project involves building a tuneable and robust synthetic oscillator. We hope that building this gene network will lead to a deeper understanding of natural biological oscillators, and have potential biomedical applications.

Giselle McCallum

Henri Thomas

Henri Thomas

MASc, Dr. Kharma's lab

My research is focused on the computational design of RNA-based circuits for selective targeting and silencing of pathogenic genes.

Henri Thomas

Iain Summerby-Murray

Iain Summerby-Murray

MSc, Dr. Martin's lab

My research is focused on identifying acid tolerance in Saccharomyces cerevisiae and developing a production host from these acidophilic yeasts.

Iain Summerby-Murray

Imge Ozugergin

Imge Ozugergin

PhD, Dr. Piekny's lab

I am studying how a DNA-sensing pathway helps set up the division plane in early C. elegans embryos. By knocking down and mutating proteins in this pathway, I will further our understanding of the pathway and identify its targets.

Imge Ozugergin

Jay Pimprikar

Jay Pimprikar

MASc, Dr. Shih’s lab

My research focuses on hybridizing synthetic biology and microfluidics to create a novel, low-cost in-vitro diagnostic for infectious disease detection. I am working on building a protein-based biosensor for rapid analyte detection at the point-of-care.

Jay Pimprikar

Jenny-Ann Gagnon

Jenny-Ann Gagnon

MSc, Dr. Shih's lab

My project is designing an automated gut-on-a-chip device that would allow the testing of several conditions in parallel. I will use the device to test different types and concentrations of chemotherapeutic agents, as well as different bacteria strains found in the gut microbiota.

Jenny-Ann Gagnon

Keegan Scott

Keegan Scott

MSc, Dr. Kwan’s lab

My research focus is on identifying and creating tools for glycan engineering. These tools will be used to humanize the glycome of yeast exosomes to develop a novel system for delivering a payload into human cells.

Keegan Scott

Kenza Samlali

Kenza Samlali

PhD, Dr. Shih's lab

My research is focused on developing novel devices for single-cell engineering and analysis. I love anything hardware/software/biology related, and preferably work across these disciplines.

Kenza Samlali

Koa Wells

Koa Wells

MASc, Dr. Kharma's lab

I am trying to develop a model for an oscillating gene circuit that will then be tested in a wet lab. The goal is for the circuit to have a short period of around 10-20 minutes.

Koa Wells

Krista Jager

Krista Jager

MSc, Dr. Potvin-Trottier's lab

I use microfluidics as a platform to study the dynamics of synthetic gene circuits at the single cell level.

Krista Jager

Manjari Shrivastava

Manjari Shrivastava

PhD, Dr. Whiteway's lab

The goal of my study is to determine the rewiring of the transcription factors in Candida albicans, an opportunistic human pathogen, as compared with Saccharomyces cerevisiae, the non-pathogenic baker’s yeast.

Manjari Shrivastava

Mathieu Husser

Mathieu Husser

PhD, Dr. Martin's lab

I am studying cellular processes by genetically engineering human cells using high-throughput equipment.

Mathieu Husser

Michelle Vandeloo

Michelle Vandeloo

MSc, Dr. Kachroo’s lab

My research aim is to create and characterize a yeast model organism with a fully humanized sterol biosynthesis pathway. This model organism will be useful to study Mendelian diseases involving genes implicated in this essential metabolic pathway.

Michelle Vandeloo

Nicolas Kamel

Nicolas Kamel

PhD, Dr. Kharma's lab

I am using machine learning to design larger riboswitch-based genetic circuits. These circuits would allow future synthetic biologists to program more complex decision-making processes into cells.

Nicolas Kamel

Nicholash Bedi

Nicholash Bedi

MASc, Dr. Shih's lab

I am using microfluidic technologies to improve culture media for clean meat production.

Nicholash Bedi

Paige Allard

Paige Allard

MSc, Dr. Potvin-Trottier’s lab

My research focuses on investigating the trade-off between metabolic burden and precision of synthetic circuits in E. coli. I use a microfluidic platform called the mother machine to observe single-cell dynamics in a tightly controlled environment.

Paige Allard

Pegah Hadavi

Pegah Hadavi

MASc, Dr. Kharma's and Dr. Perreault's labs

My research involves using synthetically generated selective riboswitches to target the transcripts of mutant proteins responsible for neurodegenerative diseases.

Pegah Hadavi

Raymond Al Homsi

Raymond Al Homsi

MSc, Dr. Whiteway's lab

I am testing the efficacy of novel antifungal drugs using high-throughput screening assays against the GRACE library of the fungal pathogen Candida albicans.

Raymond Al Homsi

Reuben Warkentin

Reuben Warkentin

MSc, Dr. Kwan's lab

My research aims to develop novel sugar binding proteins for use in cancer diagnostics and therapeutics. We are using high-throughput directed evolution in combination with computational methods to excel the production of these binding proteins.

Ruben Warkentin

Saba Mesgari

Saba Mesgari

MSc, Dr. Potvin-Trottier's and Dr. Kachroo's labs

My research aims to design a dual fluorescent reporter to quantify humanized proteasome activity in yeast. This will allow us to determine how changes to human proteasome subunits impact the rate of removal of proteins within the cell.

Saba Mesgari

Sabrine Najeh

Sabrine Najeh

PhD, Dr. Perreault's lab

I am using ribozyme design and in vitro evolution techniques to identify ribozymes that can be controlled allosterically. These ribozymes will be used to sense multiple intracellular conditions unique to cancer cells, to specifically target RNAs in order to kill these cells.

Sabrine Najeh

Sajinth Thampipillai

Sajinth Thampipillai

MSc, Dr. Wu (NRC) and Dr. Whiteway’s labs

My research project focuses on the fundamental aspects of engineering to improve GPCR signaling in yeast as a platform/tool for the study of heterologous GPCR and for potential for drug discovery.

Sajinth Thampipillai

Samuel Little

Samuel Little

PhD, Dr. Shih's lab

My project focuses on using automated liquid handling techniques to perform the genetic engineering of human immune cells. Specifically, I am interested in miniaturizing and automating the transfection and culture of mammalian cells.

Samuel Little

Sarah Laframboise

Sarah Laframboise

PhD, Dr. Baetz's lab

My research project is focused on understanding a strange phenotype in yeast called a nuclear flare which leads to a flux in membrane synthesis. Based on deletion of yeast lysine acetyltransferase, I am uncovering a role of acetylation in governing this lipid synthesis pathway.

Sarah Laframboise

Tina Papzotos

Tina Papzotos

MSc, Dr. Potvin-Trottier's lab

My research is focused on engineering E. coli populations to exhibit non-genetic heterogeneity. I am using a synthetic oscillator to achieve switching between interdependent metabolic states within a clonal population.

Tina Papzotos

Trisha Ghosh

Trisha Ghosh

MSc, Dr. Kwan's lab

My research aims to design potent inhibitory molecules for the enzyme UDP-galactopyranose mutase which is responsible for cell wall biosynthesis in Mycobacterium tuberculosis. I will utilise FIT (Flexible In vitro Translation) and RaPID systems to select molecules from a library of macrocyclic peptides and affibodies against our target.

Trisha Ghosh

Ziuwin Leung

Ziuwin Leung

MASc, Dr. Shih's lab

Project description: TBD.

Ziuwin Leung
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