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Horizon Postdoctoral Fellowships

Chronobiological mechanisms at the intersection of heart disease, brain function, and behaviour

Reference number: 14000
Supervisors: Shimon Amir and Andreas Bergdahl

Program description

The overreaching goal of our research team is to identify molecular and neural mechanisms that link progressive heart failure to brain pathology and affective disorders and to develop novel therapeutic countermeasures. To this end, we will use a mouse model of progressive heart failure based on the selective disruption of circadian clock mechanisms in heart muscle cells. Using these mice, we will study the implications of progressive heart failure on metabolism, gene expression, and neural activity in brain regions associated with affective and drug related behaviours. A range of behavioural approaches will be used to link progressive heart failure with the development of anxiety and depressive-like and drug related behaviours. Studies will be conducted in both male and female mice with the aim of identifying sex differences in mechanisms of resilience and vulnerability to the adverse effect of progressive heart failure on brain and behaviour.

Academic qualifications required

Applicants should have a PhD degree in life sciences and strong track record in molecular/cellular biology, RNA sequencing, bioinformatics and/ or biochemistry. Experience with rodent cardiovascular physiology, mouse behaviour and circadian biology will be advantageous, although not mandatory. Candidates should have interest in developing and carrying-out multidisciplinary research using diverse experimental and analytical approaches, be independent as well as team player, and be willing to engage in student mentorship.

Eligibility requirements

  • Applicants must not currently hold a postdoctoral appointment at Concordia
  • Priority will be given to postdoctoral fellows who have obtained their PhD from another university although in exceptional cases Concordia graduates may be considered
  • Applicants must adhere to the postdoctoral fellow eligibility criteria outlined in Concordia University’s Postdoctoral Policy

Timeline

Horizon position is expected to be filled as soon as possible but no later than March 1, 2024.

Submission process

  • All documents must be submitted to Shimon Amir
  • Please include the reference number with your application

Application checklist

  • One to three (1-3) page research statement demonstrating fit with the program described above 
  • Current curriculum vitae demonstrating research excellence and a capacity for leadership in the domain (maximum 5 pages)
  • Two letters of reference from academic supervisors or current employers to be sent via e-mail directly to Shimon Amir

Value

The prestigious two-year Horizon Postdoctoral Fellowships are valued at $50,000 per year plus benefits and full access to Concordia’s services, including GradProSkills.

Concordia University is a vibrant research and teaching environment, with state-of-the-art research facilities and many research centers. Concordia is located in Montreal, Canada, a diverse and creative city, often ranked as offering one of the best quality of living experiences in North America.

Concordia University is committed to Employment Equity and encourages applications from women, Aboriginal Peoples, visible minorities, ethnic minorities, and persons with disabilities.

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