Abstract: Our research focuses on the design and application of ultraminiaturized electrical circuits able to capture and probe biological molecules such as DNA and proteins. Such nanosensors allow us to follow, through alterations in the circuit electrical conductance, successive chemical reactions and conformational changes occurring on ensemble or isolated biomolecules. I will present recent high-resolution nanofabrication strategies for assembling such sensors using carbon nanotubes and graphene, as well as experiments based on this approach to explore the conformational and hybridization dynamics of DNA sequences. Finally, I will discuss our plans to expand this emerging technique towards studying fundamental mechanisms in biomolecules and for lab on a-chip biomedical technology.
Bio: Since 2017, Delphine Bouilly is Assistant-Professor (research track) in the Department of Physics at Université de Montréal, as well as Principal Investigator of the research unit in design and application of electronic nanobiosensors at the Institute for Research in Immunology and Cancer (IRIC). She is also a member of the Institute for Biomedical Engineering (U.Montréal/Polytechnique) and the Regroupement Québécois sur les Matériaux de Pointe (RQMP), and she holds the Canada Research Chair Tier 2 in bionanoelectronics. Previously, Dr. Bouilly obtained her PhD in Physics at Université de Montréal, in the laboratory of Prof. Richard Martel, and was awarded a Vanier doctoral fellowship and the André-Hamer prize from NSERC. She was then postdoctoral fellow at Columbia University in New York, in the laboratory of Prof. Colin Nuckolls. There, she was awarded the Banting postdoctoral fellowship from NSERC, after a first postdoctoral fellowship from FRQNT. Dr. Bouilly’s expertise is in nanoelectronics, biosensors and biophysics, especially in the development of electronic lab-on-a-chip sensors to detect and study biological molecules (DNA, proteins).