PERFORM Colloquium: "How Exercise Benefits to Improve Abnormal Muscle and Brain Metabolism in Diabetes"
Insulin deficiency and resistance have profound effects on skeletal muscle and brain mitochondrial biology and metabolism. The talk will focus on molecular and metabolic mechanisms on how exercise counteracts altered mitochondria metabolism in insulin resistant states.
The following will be discussed:
- Regulation of mitochondrial biogenesis and function by insulin
- Alteration of skeletal muscle and brain mitochondrial biology in insulin resistant and deficient states
- Why aerobic exercise is a countermeasure to altered mitochondrial biology in insulin resistant states
K. Sreekumaran Nair, M.D., Ph.D., is a Professor of Medicine and Endocrinologist in the Division of Endocrinology, Diabetes, Nutrition and Metabolism in the Department of Internal Medicine at Mayo Clinic Rochester. He is currently the Principal Investigator (Mayo Clinic) of NIH Molecular Transducers of Physical Activity Benefits. He is recognized as a Distinguished Investigator at Mayo Clinic with the distinction of a named professorship, the David H. Murdock-Dole Food Company Professorship.
He is a fellow of Royal College of Physicians (London), Fellow of American College of Physicians and member of American Society of Clinical Investigation and Association of American Physicians. Among many national and international awards that he has received includes E.V McCollum distinguished investigator award from American Society of Nutrition, Sir David Cuthbertson Medal and lectureship by the European Society of Clinical Nutrition and Metabolism and Honorary Doctorate and Adjunct Professorship by the Karolinska Institute, Stockholm, Sweden.
Dr. Nair’s research has a broad interest in exercise and nutritional interventions in the context of aging and metabolic disease such as obesity and diabetes and has been funded by the National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Institute of Arthritis and Musculoskeletal and Skin Diseases, American Diabetes Association, and Juvenile Diabetes Foundation. He has published total 332 papers with 263 of them original papers and 69 invited reviews or editorials.