I will discuss the current state of the art biology and mechanisms that regulate of adipose tissue leukocytes in obesity and type 2 diabetes. Integrative studies in humans and mice will be discussed.
The purpose of this talk is to:
Understand the role the adipose tissue immune system plays in nutrient regulation
Understand the diversity of functions of adipose tissue macrophages
Compare and contrast immunometabolism findings in humans and mouse models
Carey Lumeng M.D. Ph.D. is the Frederick Huetwell Professor for the Cure and Prevention of Birth Defects and Associate Professor in the Department of Pediatrics at the University of Michigan Medical School. He is a graduate of Princeton University where he majored in Molecular Biology. He then obtained his MD and PhD from the University of Michigan Medical Scientists Training Program (MSTP) with a PhD in Human Genetics studying muscular dystrophy. He completed training in Pediatrics from the Boston Combined Residency Program in Pediatrics at Boston Children’s Hospital and Boston Medical Center and returned to the University of Michigan for his Fellowship in Pediatric Pulmonology where he studied obesity-induced inflammation with Alan Saltiel Ph.D. During his fellowship training, he completed studies evaluating the function of adipose tissue macrophages in obesity that advanced the model of macrophage polarization in adipose tissue macrophages.
His independent laboratory has maintained a focus on the function of adipose tissue macrophages in obesity and diabetes. Projects center on macrophage control of T cell function, macrophage proliferation as a mechanism of control, crosstalk between macrophages and preadipocytes, and regulation of adipose tissue macrophages in human obesity. He has been funded by the NIH and the American Diabetes Association since 2007. He is an Associate Editor for Diabetes and member of the editorial board for JCI Insight. He is a member of the NIH IPOD (Integrative Physiology of Obesity and Diabetes) study section.