PERFORM Colloquium - Big data for precision medicine: charting resting-state functional connectivity & connectopies
Large clinical and population cohort neuroimaging resources are increasingly coming online, forming a new field of imaging epidemiology. These offer a unified perspective that links brain connectional organization to behaviour and cognition. Currently, however, the full potential of these resources for understanding brain connectivity is not being realized. This is due to a lack of suitable analysis tools that explore relationships between and integrate across modalities, are sensitive to subtle changes in individual connectivity profiles and provide a means to move beyond simple case-control analysis towards understanding inter-individual differences in connectivity. In this talk I will outline novel approaches for charting the organisation of functional connectivity and introduce a ‘normative modelling’ strategy for utilising big cohort data for generating individualised predictions with application in clinical neuroimaging studies.
- Audience member will be introduced to novel approaches for characterizing functional connectivity in the brain and how to use large cohort studies to make valuable predicitions at the level of an individual patient in clinical imaging neuroscience studies
Prof Beckmann is the Chair of Statistics in Imaging Neuroscience at the Donders Centre for Cognitive Neuroimaging, Nijmegen (NL) and a Senior Research Fellow at the FMRIB Centre of the University of Oxford (UK). His research focus is on developing novel methods for imaging neurosciences. Prof Beckmann leads a multi-disciplinary team with research foci that cover a range of subjects from the analysis of Neuroimaging data, via the development of novel tools for general image and signal processing, to the technology development for imaging biomarkers and advanced diagnosis systems for the neural system. In doing so, we the group uses a variety of imaging techniques, such as MRI, FMRI, MEG, EEG etc and integrate this with other types of data, such as Genetic or questionnaire information.