Concordia University

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Grova Research Group

The Multimodal Functional Imaging Laboratory, directed by Dr. Christophe Grova, is a multidisciplinary team composed of neurologists and methodologists. The laboratory is actually based on two sites:

  • Biomedical Engineering Department and part of the epilepsy group of the Montreal Neurological Institute, McGill University
  • Department of Physics and PERFORM Centre, Concordia University

We investigate multimodal data fusion to characterize brain mechanisms and especially epileptic activity. Our research project aims at developing methods to appropriately combine multimodal data in order to detect additional information that could be missed by considering each modality individually. A typical challenge is to combine modalities directly measuring neuronal activity with high temporal resolution with other modalities indirectly measuring the same function with high spatial resolution, through hemodynamic processes for instance. The project will involve the integration of three promising functional modalities:

  1. Simultaneous ElectroEncephaloGraphy (EEG) - MagnetoEncephaloGraphy (MEG) acquisitions, measuring directly on the scalp electric and magnetic components of signals generated by neurons synchronously active (at a ms scale).
  2. Simultaneous EEG - functional Magnetic Resonance Imaging (fMRI) acquisitions to measure, within the whole brain at a second scale, hemodynamic responses that correlate with signals detected on scalp EEG.
  3. Simultaneous EEG - Near InfraRed Spectroscopy (NIRS) acquisitions to measure local changes in oxy- and deoxy-hemoglobin at the time of signals detected on scalp EEG, by exploiting absorption properties of infrared light within brain tissues using optic fibres placed on the surface of the head. Note that our EEG/NIRS laboratory is located in Biomedical Engineering dpt and easily accessible from the McConnell Brain Imaging Centre.

The principal clinical application of this project will be to combine these three modalities using multimodal data fusion techniques to characterize brain regions involved during epileptic activity.  

Multi FunkIm Research

Using cutting-edge non invasive methods involving simultaneous EEG/MEG, EEG/fMRI and EEG/NIRS recordings, our objectives consist in proposing:

Multi FunkIm Members

Multi FunkIm EEG/NIRS Laboratory

Our EEG/NIRS laboratory equipped with a 64 channels EEG device (Stellate) and a 32×32 Brainsight NIRS device (Rogue-Research Inc.) as well as all the needed equipment to set up experiments (e-prime, Digitimer electric stimulator, TMS). The laboratory is located in Department of Biomedical Engineering, in room 332 of the Lyman Duff Building, easily accessible from the BIC. Please contact us if interested in new collaborations involving this device.

Location: 332 Duff Medical Building, 3775 Rue University, Montréal, QC, H3A 2B4, Canada

Multi FunkIm EEG/NIRS Laboratory

Articles in Peer-Reviewed Journals

2018

2017

2016

2015

2014

2013

2012

2011

2009

2008

2007

2006

2005

2003

2001

  • Jannin P., Grova C., and Gibaud B. Fusion de données : Une revue méthodologique basée sur le contexte clinique, ITBM-RBM Innovation et technologie en biologie et médecine, 22(4) pp. 196–215 (2001)

2000

Reviews, Book Chapters, Books

Published Proceedings in International Conferences: Peer-reviewed in Extenso Articles

Published Proceedings in International Conferences: Peer-reviewed Long Abstracts

  • Batan G., Reilhac A., Grova C., Collins D.L., Tohka J., Costes N. and Evans, A.C., “A Database of Simulated PET Volumes with Anatomical Variability”, ‘’Nuclear Science Symposium Conference Record, 2004, IEEE vol 6,  16–22 Oct 2004, pp. 3699 – 3702 (2004)
  • Perruchot F., Reilhac A., Grova C., Evans A.C. and Dagher, A, “Motion Correction of Multi-Frame PET Data”, ‘’Nuclear Science Symposium Conference Record, 2004 IEEE vol 5,  16–22 Oct. 2004, pp. 3186 – 3190 (2004)
  • Scarabin J.M., Aubert-Broche B., Grova C., Argaud C., Schaeffer M., and Jannin P. , “Perfusion Weighted MRI: A New Tool for Epilepsy Surgery”, In Computer Assisted Radiology and Surgery 2002. Edited by H.U. Lemke, M.W. Vannier, K. et al, Springer, pp361-−365 (2002)
  • Grova C., Jannin P., Biraben A., Buvat I., Benali H., Bernard A.M., Scarabin J.M., and Gibaud B., “Validation of MRI/SPECT Similarity-Based Registration Methods using Realistic Simulations of Normal and Pathological SPECT Data”, In Computer Assisted Radiology and Surgery 2002, Edited by H.U. Lemke, M.W. Vannier, K. et al, Springer, pp361-−365 (2002). (oral presentation)
  • Jannin P., Fleig O.J., Seigneuret E., Grova C., Morandi X., and Scarabin J.M. Multimodal and Multi-Informational Neuro-Navigation, In Computer Assisted Radiology and Surgery 2000, Edited by H.U. Lemke, M.W. Vannier, et al, Elsevier, pp 167–172 (2000)
  • Jannin P., Schwartz D., Grova C., Barillot C. and Gibaud B. Fusion of multimodal functional neuro-imaging (MEG, fMRI, SPECT): definition of different matching paradigms, In Computer Assisted Radiology & Surgery 1999, Edited by H.U. Lemke, M.W. Vannier, et al, Elsevier, pp

Abstracts and Conference Presentations

2018

  • Kangjoo Lee, Hui Ming Khoo, Jean-Marc Lina, Francois Dubeau, Jean Gotman and Christophe Grova, “Identification of epileptic networks involving connector hubs in mesial temporal lobe epilepsy”, The 24th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 2018, Singapore (Poster session)

2017

  • Hedrich T., Aydin Ü., Jegou A., Grimault S., Benali H., Grova C., “Electrical source imaging of visual evoked responses inside the MR scanner”, Organisation for Human Brain Mapping, Vancouver, Canada, June 2017

2016

  • Hedrich T., Khoo H.M., Pellegrino G., Aydin Ü., Gotman J., Grova C. “Reproducibility of distributed electrical source imaging of interictal discharges inside and outside the MR scanner and concordance with hemodynamic changes”, American Epilepsy Society Annual Conference – AES 2016, Houston, Texas, December 2016 (accepted for poster presentation)
  • Kangjoo Lee, Hui Ming Khoo, Jean-Marc Lina, Jean Gotman and Christophe Grova, “Resting state fMRI reveals abnormal reorganization of network hubs in mesial temporal lobe epilepsy”, The 70th American Epilepsy Society (AES) Annual Meeting, December 2016, Houston, USA (Accepted for Poster session)
  • Kangjoo Lee, Hui Ming Khoo, Jean Gotman and Christophe Grova, “Reorganization of Functional Hubs and Overlapping Networks in Mesial Temporal Lobe Epilepsy”, The 22th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 2016, Geneva, Switzerland (accepted for poster presentation)
  • Kangjoo Lee, Hui Ming Khoo, Jean-Marc Lina, Jean Gotman and Christophe Grova, “Detection of functional hubs from resting state fMRI data and their reorganization in Mesial Temporal Lobe Epilepsy”, The 3rd Whistler Scientific Workshop on Brain Functional Organization, Connectivity and Behavior, March 2016, Whistler-Blackcomb, B.C., Canada (accepted for oral presentation)

2015

  • Kangjoo Lee, Jean-Marc Lina, Jean Gotman, Christophe Grova, “Reliable Detection of Functional Connector Hubs and Overlapping Network Structure in Resting-State fMRI using SPARK”, Biological & Biomedical Engineering Symposium, September 2015, Montreal, Canada (First Place Winner, Poster Competition 2)
  • Chowdhury R., Pellegrino G, Ellenreider N.V., Kobayashi E., Lina JM, Grova C. “Fusion of EEG and MEG increases the spike-to-spike reproducibility rate”, Basic and Clinical multimodal Imaging (BaCI), September 2015, Utrecht, Netherlands. (accepted for poster presentation)
  • Chowdhury R., Pellegrino G, Ellenreider N.V., Kobayashi E., Lina JM, Grova C. “Clinical relevance of EEG-MEG Fusion Source Analysis of Inter-ictal spikes”, 2015 Annual Meeting of the American Epilepsy Society, December 2015, Philadelphia, PA, USA. (accepted for poster presentation)
  • Hedrich T, Aydin Ü, Jegou A, Pellegrino G, Lina JM, Grova C. “Comparison of Electrical Source Imaging and Ballistocardiogram Artefact Correction Methods Using Somatosensory Evoked Responses in hdEEG-fMRI”, Basic and Clinical multimodal Imaging (BaCI), September 2015, Utrecht, Netherlands.
  • Kangjoo Lee, Jean-Marc Lina, Jean Gotman, Christophe Grova, “Organization of Functional Hubs in Healthy Human Brain”, The 2nd Annual PERFORM Centre Research Conference, May 2015, Montreal, Canada (Winner of the best poster presentation)

2014

  • Pellegrino G., Machado A., Watanabe S., Drouin N., Allard L., Lina J.M., Hall J., Kobayashi E., Grova C., “Personalized simultaneous EEG-NIRS to assess the neurovascular coupling in focal epilepsy”, fNIRS 2014, Montreal, Canada, October 2014 (accepted for oral presentation)
  • Pellegrino G., Machado A., Watanabe S., Drouin N., Allard L., Lina J.M., Hall J. 2, Kobayashi E.2, Grova C., “Simultaneous EEG-NIRS (Near InfraRed Spectroscopy) guided by MEEG and EEG-fMRI to assess the neurovascular coupling in focal epilepsy: a new, non-invasive, multimodal approach”, 68th Annual Meeting of the American Epilepsy Society, Seattle, USA, December 2014 (accepted for poster presentation)
  • Brahim Belaoucha, Jean-Marc Lina, Maureen Clerc, Anne-Charlotte Philippe, Christophe Grova, et al.. Using diffusion MRI information in the Maximum Entropy on Mean framework to solve MEG/EEG inverse problem. The 19th International Conference on Biomagnetism, Aug 2014, Halifax, Canada.
  • Hedrich T., Lina JM, Kobayashi E and Grova C. “Analysis of spatial resolution and crosstalk of different distributed source localization methods in EEG and MEG”, 10th International Conference on Biomagnetism - BIOMAG 2014, Halifax, Canada, August 2014 (accepted for poster presentation)
  • Chowdhury R., Merlet I., Birot G., Albera L., Kobayashi E., Lina J.M., Wendling F., Grova C. “Localization of the spatial extent of the generators of epileptic discharges in EEG and MEG: comparison between 4-ExSo-MUSIC and MEM approaches”, 19th International Conference on Biomagnetism - BIOMAG 2014, Halifax, Canada, August 2014 (accepted for poster presentation)
  • Chowdhury R., Zerouali Y., Hedrich T., Heers M., Kobayashi E., Lina J.M., GrovaC. “Localization of generators of epileptic activity using fusion of EEG and MEG data”, Neuro Epilepsy Day, Montreal Neurological Institute, Montreal, Canada, March 2014. (Accepted for oral presentation)
  • Lee. K., Lina J-M., Gotman J., Grova C., “SPARK: Sparsity-based Analysis for Reliable k-hubness in Brain Functional Connectivity”, The 20th Annual Meeting of the Organization for Human Brain Mapping (OHBM), June 2014, Hamburg, Germany (accepted for poster presentation)
  • Grova C., Dansereau C. L., Bellec P., Lee K., Pittau F., Gotman J., “Detection of Abnormal resting-state Networks in Individuals (DANI): application in epilepsy”, The 2nd Whistler Scientific Workshop on Brain Functional Organization, Connectivity and Behavior, March 2014, Whistler-Blackcomb, B.C., Canada (accepted for oral presentation)

2013

  • Lee K., Lina J-M., Gotman J., Grova C., “Characterization of stability in sparse brain network for resting-state fMRI”, Workshop on Scale-free Dynamics and Networks in Neuroscience, October 2013, Montreal, Canada (Poster session)
  • Grova C., Chowdhury R., Hedrich T., Heers M., Zelmann R., Hall J.A., Lina J.M., Kobayashi E. Evaluation of the spatial extent of the sources of epileptic spikes in MEG. Clinical EEG and Neuroscience. International Conference on Basic and Clinical Multimodal Imaging (BACI), Geneva, September 5–8 2013 (Invited talk)
  • Cisneros-Franco J.M., Lina J-M., Grova C. and Kobayashi E. Time Frequency Analysis of Ictal MEG signals using Wavelet-based Maximum Entropy of the Mean (wMEM). IEC Montreal 2013, Epilepsia, (54)s3 p.171 (accepted for poster)
  • Heers M., Hedrich T., An D., Gotman J., Grova C. and Kobayashi E. Concordance of EEG-fMRI BOLD responses and magnetic source imaging (MSI) of epileptic spikes in patients with focal epilepsy. IEC Montreal 2013, Epilepsia, (54)s3 p.10 (accepted for oral presentation)
  • Maneshi M., Grova C. and Gotman J. A new data-driven method detects whole brain functional connectivity changes in IGE patients. IEC Montreal 2013, Epilepsia, (54)s3 p.10. (accepted for oral presentation)
  • Lee K., Gotman J. and Grova C. Bootstrap Analysis of Stability in Sparse Dictionary Learning for Resting-State fcMRI. In Proceedings of Human Brain Mapping 2013, Seattle USA, (accepted for poster)

2012

  • Grova, C., Aiguabella, M., Lina, J.M., Hall J.A. and Kobayashi E., Intracranial EEG potentials simulated from MEG sources: a new approach to evaluate the spatial extent of MEG sources from IEEG measurements, Proc. of American Epilepsy Society, San Diego 2012, (accepted for poster)
  • Hedrich T., Kobayashi E, Lina JM and Grova C. Accuracy of spatio-temporal reconstruction using entropic technique from MEG data. In: 18th International Conference on Biomagnetism - BIOMAG 2012; Paris, 2012 (accepted for poster)
  • Chowdhury R., Zerouali Y., Lina J.M., Kobayashi E. and Grova C. Multimodal EEG/MEG fusion within the Maximum Entropy on the Mean (MEM) framework In: 18th International Conference on Biomagnetism - BIOMAG 2012; Paris, 2012 (accepted for poster)
  • Zerouali Y., Chowdhury R., Jemel B., Grova C. and Lina. Wavelet-based localization of oscillatory and synchronous sources in Brainstorm In: 1st Brainstorm User Symposium, satellite at the 18th International Conference on Biomagnetism - BIOMAG 2012; Paris, 2012 (oral presentation)
  • Maneshi M., Vahdat S., Grova C. and Gotman J. Validation of a new ICA-based method for between-group comparisons in fMRI, Proceedings of Human Brain Mapping 2012, Beijing, China, (accepted for poster)
  • Vahdat S., Maneshi M., Grova C., Gotman J. and Milner T. Shared and Specific Independent Components Analysis for Between Groups Comparison, Proceedings of Human Brain Mapping 2012, Beijing, China, (accepted for poster)

2011

  • Machado A., Rosenberg D., Lina J.M., Kobayashi E. and Grova C. Estimation of hemodynamic responses to epileptic activity using EEG/NIRS acquisitions. Proceedings of Human Brain Mapping 2011, Quebec, (accepted for poster)
  • Lina J.M., lemay E., Chowdhury R., Hall J., Kobayashi E. and Grova C. Localization of oscillatory MEG activity combing time-frequency analysis and entropic inference. Proceedings of Human Brain Mapping 2011, Quebec, (accepted for poster and e-poster presentation)
  • Pittau F., Grova C., Moeller F., Dubeau F. and Gotman J. FMRI functional connectivity study in Mesial Temporal Lobe Epilepsy. Proceedings of Human Brain Mapping 2011, Quebec, (accepted for poster)
  • Langlois Dansereau C., Pittau F., Bellec P., Gotman J. and Grova C. Detection of abnormal resting state networks in epileptic patients. Proceedings of Human Brain Mapping 2011, Quebec, (accepted for poster)
  • Maneshi M., Moeller F., Gotman J. and Grova C. Functional Connectivity in Patients with Generalized Epilepsy. Proceedings of Human Brain Mapping 2011, Quebec, (accepted for poster and e-poster presentation)
  • Jones M.L., Crippa A.C., Lina J.M., Grova C. and Kobayashi E. MEG source localization of interictal bursts of epileptic activity in time frequency domain. Proceedings of Human Brain Mapping 2011, Quebec, (accepted for poster)
  • Aiguabella M, Grova C., Sangani M., Rosenberg D. , Zelmann R., Hall J, Gotman J., Dubeau F. and Kobayashi E. Anatomical correlation between magnetoencephalography and intracranial EEG recordings, Proceedings of Human Brain Mapping 2011, Quebec, (accepted for poster)
  • Jones M.L., Lina J.M., Grova C. and Kobayashi E. Source Localization of Oscillatory Components in Bursts of Interictal Rhythmic Epileptic Activity. Proceedings of American Academy of Neurology 2011, Hawai, (accepted for poster)

2010

  • Chowdhury R., Potiez Y., Sangani S., Lina J.M., Kobayashi E. and Grova C. Maximum entropy on the Mean for source localization of epileptic activity in MEG. Proceedings of Human Brain Mapping 2010, Barcelona, (accepted for poster)

2009

  • Machado A., Lina J.M., Lesage F. and Grova C. Detection of hemodynamic responses to epileptic activity using EEG/NIRS simultaneous acquisitions. Proc. of American Epilepsy Society, Boston 2009, (accepted for poster)
  • Grova C., Moeller F., Kobayashi E., Gholipour T., Pittau F., Bellec P., Dubeau F. and Gotman, J. Functional connectivity of medial thalamus is altered in patients with idiopathic generalized epilepsy compared to healthy controls. Proc. of American Epilepsy Society, Boston 2009, (accepted for poster)

2008

  • Grova C., Kobayashi E., Potiez Y., Dubarry A-S., Tyvaert L, Lina JM, Dubeau F, Jolicoeur P and Gotman J. Multimodal data analysis of epileptic activity: comparison between cortical sources localized from EEG and MEG data and BOLD responses detected in EEG-fMRI studies. Proc. of American Epilepsy Society, Seattle 2008, (accepted for poster)

2007

  • Grova C., Kobayashi E., Tyvaert L, Lina JM, Dubeau F, Jolicoeur P and Gotman J . Magnetoencephalogram of interictal spike activity: correlation with BOLD responses in EEG-fMRI studies. Proceedings of American Epilepsy Society conference, Philadelphia 2007(accepted for poster)
  • Kobayashi E, Grova C, Tanaka N, Stufflebeam S, Hämäläinen M Contribution of distributed source analyses of MEG signal to the understanding of epileptic networks in focal cortical dysplasia. Proceedings of American Epilepsy Society conference, Philadelphia 2007 (accepted for poster)
  • Grova C., Lina J.M., Daunizeau J., Dubarry A.S., Gotman J. and Jolicoeur P. MEG source localization of single trial versus average data : an evaluation using realistic simulations. Proceedings of Human Brain Mapping 2007, Chicago, (accepted for poster)
  • Grova C., Kobayashi E., Hawco C., Dubeau F. and Gotman J. Identification of a network associated with BOLD responses to epileptic spikes using multivariate group analysis in Temporal Lobe and Generalized Epilepsies. Proceedings of Human Brain Mapping 2007, Chicago, (accepted for poster)
  • Grimault, S., Robitaille, N., Grova, C., Lina, J.-M., Dubarry, A.-S., and Jolicoeur P. A novel method of source localization of magnetoencephalographic (MEG) induced activity applied in visual short-term memory Proceedings of Human Brain Mapping 2007, Chicago, (accepted for poster)
  • Jolicoeur, P., Grimault, S., Robitaille, N., Lina, J.-M., Grova, C., and Dubarry, A.-S. Induced oscillatory activity during retention in visual short-term memory. Poster presented at the 47th Annual Meeting of the Society for Psychophysiological Research. Savannah, Georgia, USA, October 17−21. 2007

2006

  • Grova C., Kobayashi E., Hawco C., Dubeau F. and Gotman J. BOLD response in Temporal Lobe Epilepsy using Group Analysis. Proceedings of Human Brain Mapping 2006, Florence, (accepted for poster)
  • Kobayashi E., Grova C., Hawco C., Dubeau F. and Gotman J. Assessing the lesional and perilesional BOLD responses in malformations of cortical development. Proceedings of Human Brain Mapping 2006, Florence, accepted

Before 2005

  • Grova C., Daunizeau J., Bagshaw A.P., Kobayashi E., Lina J.M., Dubeau F. and Gotman J. Assessing the concordance between EEG source localization and simultaneous EEG/fMRI studies. In American Epilepsy Society (AES) 2005 Washington. (2005). (accepted for poster)
  • Kobayashi E., Bagshaw A.P., Grova C., Dubeau F. and Gotman J. Negative BOLD responses to interictal epileptic spikes. Epilepsia 2005;46(Suppl 6): 172
  • Grova C., Daunizeau J., Lina J.M., Bénar C., Benali H. and Gotman J. Evaluation of EEG localization methods using realistic simulations of interictal spikes. Proceedings. of Human Brain Mapping 2005, Toronto, CD-ROM (poster)
  • Makni S., Grova C., Flandin G., Ciuciu P., Poline J.B. An interpolation method for fMRI data extraction on the cortical surface. Proceedings of Human Brain Mapping 2005, Toronto, CD-ROM
  • Lu Y., Grova C., Bagshaw A.P., Kobayashi E., Dubeau F. and Gotman J. EEG-fMRI Data Analysis: Fixed or Voxel-wise Hemodynamic Response Function? Proceedings. of Human Brain Mapping 2005, Toronto, CD-ROM
  • Daunizeau J., Grova C., Mattout J., Lina J.M. and Benali H. Assessing the relevance of fMRI-derived prior in the EEG/MEG inverse problem: a Bayesian Model Comparison approach. Proceedings. of Human Brain Mapping 2005, Toronto, CD-ROM
  • Bénar C.G., Agha Khani Y., Kobayashi E., Bagshaw A.P., Grova C., Dubeau F. and Gotman J. Simultaneous EEG-fMRI of Epileptic Spikes: Comparison of fMRI and EEG Statistical Maps with Intracranial Recordings. 10th Annual Meeting of the Organization for Human Brain Mapping, Budapest, June 2004. CD-ROM
  • Grova C., Biraben A., Jannin P., Gibaud B. and Scarabin J.M. Modelling of normal and ictal perfusion patterns in SPECT using correspondence analysis. In American Epilepsy Society (AES) 2003 Boston. (2003). (poster)
  • Grova C., Jannin P., Biraben A., Scarabin J. M. and Gibaud B. Multimodal data fusion: state of the art, issues and perspectives. Application: SPECT/MRI data fusion in epilepsy. Neurophysiologie Clinique / Clinical Neurophysiology , 32(2) p. 9 (2002). Invited Conference (oral presentation)
  • Grova C., Jannin P., Biraben A., Scarabin J. M., Benali H., and Gibaud B. Generation of realistic models of ictal SPECT using Monte Carlo simulations. In Neuroimage (HBM 2001), Edited by Toga A.W., Frackowiak R.S, and Mazziotta J.C., 13 (6), pp S137 (2001). (poster)
  • Biraben A. and Grova C. Ictal SPECT in frontal seizures : Correlations with SEEG recordings. In 4th European Congress on Epileptology Proceedings, Epilepsia, 41, pp 3–4 (2000). Invited Conference. (oral presentation)
  • Grova C., Jannin P., Biraben A. and Scarabin J. M. Fusion de données anatomo-fonctionnelles pour l’aide au diagnostic des épilepsies pharmaco-résistantes : Problématique de la validation. In Epilepsies (JFE 2000) John Libbey Eurotext, 12 pp 256–257 (2000). (oral presentation)
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